CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgical Pain in Rats

CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgical Pain in Rats

Purpose. Caveolae (CAV) are an invaginated microcapsule with the shape of Ω on the surface of the cell membrane. Caveolin-1 (CAV-1) is involved in neuropathic pain, and adenosine monophosphate (AMP)-exchange protein directly activated by cAMP1 (EPAC-1) is a potential therapeutic target for chronic p...

Full description

Bibliographic Details
Main Authors:	Qian Hua, Shiren Shen, Yibin Qin, Su Cao
Format:	Article
Language:	English
Published:	Hindawi Limited 2022-01-01
Series:	Pain Research and Management
Online Access:	http://dx.doi.org/10.1155/2022/8566840

Similar Items

Role of EPAC1 in chronic pain
by: Chenlu Jiang, et al.
Published: (2024-03-01)

EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury
by: Samantha C. Berkey, et al.
Published: (2020-01-01)

Structure-guided design of selective Epac1 and Epac2 agonists.
by: Frank Schwede, et al.
Published: (2015-01-01)

Skin/muscle incision and retraction regulates the persistent postoperative pain in rats by the Epac1/PKC-βII pathway
by: Jiashu Qian, et al.
Published: (2022-07-01)

Blood-nerve barrier enhances chronic postsurgical pain via the HIF-1α/ aquaporin-1 signaling axis
by: Pei-zhi Wu, et al.
Published: (2023-11-01)

Effect of acute postsurgical pain trajectories on 30-day and 1-year pain
by: Saria S. Awadalla, et al.
Published: (2022-01-01)

Effect of acute postsurgical pain trajectories on 30-day and 1-year pain.
by: Saria S Awadalla, et al.
Published: (2022-01-01)

Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation
by: Viktor N. Tomilin, et al.
Published: (2022-02-01)

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.
by: Parnell, E, et al.
Published: (2012)

GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure
by: Marion Laudette, et al.
Published: (2021-01-01)

Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids
by: João F. Ferreira, et al.
Published: (2022-07-01)

Role of EPAC1 Signalosomes in Cell Fate: Friends or Foes?
by: Karina Formoso, et al.
Published: (2020-08-01)

The mechanisms and management of persistent postsurgical pain
by: Alice M. Fuller, et al.
Published: (2023-07-01)

Evaluation of Rap1GAP and EPAC1 gene expression in endometriosis disease
by: Mehran Dehghanian, et al.
Published: (2023-01-01)

The Role of Epac in Cancer Progression
by: Nadine Wehbe, et al.
Published: (2020-09-01)

EPAC1 inhibition protects the heart from doxorubicin-induced toxicity
by: Marianne Mazevet, et al.
Published: (2023-08-01)

Recalcitrant Hypocalcemia: Postsurgical Hypoparathyroidism Exacerbated by a Chyle Leak Treated With Octreotide
by: Brenda Dorcely, MD, et al.
Published: (2024-03-01)

Management of chronic postsurgical pain following cholecystectomy
by: Parthasarathy Srinivasan, et al.
Published: (2018-01-01)

EPAC in Vascular Smooth Muscle Cells
by: Nadine Wehbe, et al.
Published: (2020-07-01)

Cycling Infrastructure for All EPACs Included?
by: Nikolaas Van den Steen, et al.
Published: (2022-04-01)

Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes
by: Ryan B. Griggs, et al.
Published: (2019-07-01)

Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription
by: Liliana Felicia Iannucci, et al.
Published: (2023-09-01)

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling
by: Candice Sartre, et al.
Published: (2023-07-01)

Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice.
by: Yuan Zhang, et al.
Published: (2011-01-01)

Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain
by: Qi Li, et al.
Published: (2019-12-01)

CLINICAL AND LABORATORY CHANGES IN POSTSURGICAL PAIN MARKERS IN CHILDREN
by: Я. Семкович
Published: (2023-10-01)

Capsaicin 8% Patch and Chronic Postsurgical Neuropathic Pain
by: Luca Gregorio Giaccari, et al.
Published: (2021-09-01)

The role of anxiety and related states in pediatric postsurgical pain
by: Cheryl H. T. Chow, et al.
Published: (2020-12-01)

Chronic postsurgical pain: still a neglected topic?
by: Kissin I, et al.
Published: (2012-11-01)

Persistent Postsurgical Pain in Oral Cancer Patients Reconstructed with Anterolateral Thigh Free Flap
by: Ya-Chun Shen, et al.
Published: (2022-03-01)

RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis.
by: Xiulian Sun, et al.
Published: (2014-01-01)

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1
by: Lobo, MJ, et al.
Published: (2016)

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1
by: Zaccolo, M, et al.
Published: (2016)

Pharmacological Inhibition of Epac1 Averts Ferroptosis Cell Death by Preserving Mitochondrial Integrity
by: Nshunge Musheshe, et al.
Published: (2022-02-01)

Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1
by: Hanna K. Buist, et al.
Published: (2021-09-01)

Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation
by: Bastien Guillot, et al.
Published: (2023-02-01)

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
by: Ponsioen, B, et al.
Published: (2004)

Prognostic Value of CAV1 and CAV2 in Head and Neck Squamous Cell Carcinoma
by: Jingyu He, et al.
Published: (2023-02-01)

Sprayable gel for postsurgical immunotherapy
by: Qian Chen, et al.
Published: (2019-09-01)

Modulating Influence of State Anxiety on the Effect of Midazolam on Postsurgical Pain
by: Caroline Dahlem, et al.
Published: (2023-04-01)