A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge

Histoplasma capsulatum is a geographically specific dimorphic fungus that can cause a spectrum of diseases. While most cases are asymptomatic pulmonary infections, in severe cases, particularly in immunocompromised patients, disseminated disease can occur. Histoplasmosis in California is limited to...

Full description

Bibliographic Details
Main Authors: Ameish Govindarajan MD, Rowis Sous MD, Frederick Venter MD, Tyler Torrico MD, Natalie Karapetians MD, Arash Heidari MD, Everardo Cobos MD, Greti Petersen MD
Format: Article
Language:English
Published: SAGE Publishing 2023-02-01
Series:Journal of Investigative Medicine High Impact Case Reports
Online Access:https://doi.org/10.1177/23247096231156007
_version_ 1797903859208683520
author Ameish Govindarajan MD
Rowis Sous MD
Frederick Venter MD
Tyler Torrico MD
Natalie Karapetians MD
Arash Heidari MD
Everardo Cobos MD
Greti Petersen MD
author_facet Ameish Govindarajan MD
Rowis Sous MD
Frederick Venter MD
Tyler Torrico MD
Natalie Karapetians MD
Arash Heidari MD
Everardo Cobos MD
Greti Petersen MD
author_sort Ameish Govindarajan MD
collection DOAJ
description Histoplasma capsulatum is a geographically specific dimorphic fungus that can cause a spectrum of diseases. While most cases are asymptomatic pulmonary infections, in severe cases, particularly in immunocompromised patients, disseminated disease can occur. Histoplasmosis in California is limited to only a few case reports. In this article, we describe a rare case of disseminated histoplasmosis in a non-endemic region presenting with diagnostically challenging symptomatology, including altered mental status, status epilepticus, septic shock, and bilateral adrenal masses.
first_indexed 2024-04-10T09:39:32Z
format Article
id doaj.art-36d85ef9a8304091b4303cb7a197f59b
institution Directory Open Access Journal
issn 2324-7096
language English
last_indexed 2024-04-10T09:39:32Z
publishDate 2023-02-01
publisher SAGE Publishing
record_format Article
series Journal of Investigative Medicine High Impact Case Reports
spelling doaj.art-36d85ef9a8304091b4303cb7a197f59b2023-02-17T13:03:34ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962023-02-011110.1177/23247096231156007A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic ChallengeAmeish Govindarajan MD0Rowis Sous MD1Frederick Venter MD2Tyler Torrico MD3Natalie Karapetians MD4Arash Heidari MD5Everardo Cobos MD6Greti Petersen MD7Department of Medicine, Kern Medical UCLA, Bakersfield, USADepartment of Medicine, Kern Medical UCLA, Bakersfield, USADepartment of Medicine, Kern Medical UCLA, Bakersfield, USADepartment of Psychiatry, Kern Medical UCLA, Bakersfield, USADepartment of Medicine, Kern Medical UCLA, Bakersfield, USADivision of Infectious Diseases, Department of Medicine, Kern Medical UCLA, Bakersfield, USADepartment of Medicine, Kern Medical UCLA, Bakersfield, USADepartment of Medicine, Kern Medical UCLA, Bakersfield, USAHistoplasma capsulatum is a geographically specific dimorphic fungus that can cause a spectrum of diseases. While most cases are asymptomatic pulmonary infections, in severe cases, particularly in immunocompromised patients, disseminated disease can occur. Histoplasmosis in California is limited to only a few case reports. In this article, we describe a rare case of disseminated histoplasmosis in a non-endemic region presenting with diagnostically challenging symptomatology, including altered mental status, status epilepticus, septic shock, and bilateral adrenal masses.https://doi.org/10.1177/23247096231156007
spellingShingle Ameish Govindarajan MD
Rowis Sous MD
Frederick Venter MD
Tyler Torrico MD
Natalie Karapetians MD
Arash Heidari MD
Everardo Cobos MD
Greti Petersen MD
A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge
Journal of Investigative Medicine High Impact Case Reports
title A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge
title_full A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge
title_fullStr A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge
title_full_unstemmed A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge
title_short A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge
title_sort case of disseminated histoplasmosis from california in the setting of secondary hemophagocytic lymphohistiocytosis a diagnostic challenge
url https://doi.org/10.1177/23247096231156007
work_keys_str_mv AT ameishgovindarajanmd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT rowissousmd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT frederickventermd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT tylertorricomd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT nataliekarapetiansmd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT arashheidarimd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT everardocobosmd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT gretipetersenmd acaseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT ameishgovindarajanmd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT rowissousmd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT frederickventermd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT tylertorricomd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT nataliekarapetiansmd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT arashheidarimd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT everardocobosmd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge
AT gretipetersenmd caseofdisseminatedhistoplasmosisfromcaliforniainthesettingofsecondaryhemophagocyticlymphohistiocytosisadiagnosticchallenge