The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients
Aim: Fibrinogen and albumin are proteins that play a role in inflammation. In this study, it was aimed to investigate the role of fibrinogen, albumin, and fibrinogen/albumin ratio (FAR) levels as markers of disease severity and prognosis in coronavirus disease 2019 (COVID-19) patients. Material and...
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| Format: | Article |
| Language: | English |
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Duzce University
2022-08-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/2393110 |
| _version_ | 1797421038503460864 |
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| author | Dilcan Kotan Saadet Sayan Elif Sarıca Darol Esen Çiçekli |
| author_facet | Dilcan Kotan Saadet Sayan Elif Sarıca Darol Esen Çiçekli |
| author_sort | Dilcan Kotan |
| collection | DOAJ |
| description | Aim: Fibrinogen and albumin are proteins that play a role in inflammation. In this study, it was aimed to investigate the role of fibrinogen, albumin, and fibrinogen/albumin ratio (FAR) levels as markers of disease severity and prognosis in coronavirus disease 2019 (COVID-19) patients.
Material and Methods: Seventy-one patients aged between 19 and 84 years diagnosed with COVID-19 who were hospitalized in Sakarya University Training and Research Hospital, Neurology Department between March and May 2020 were analyzed retrospectively. Fibrinogen, albumin, FAR, D-dimer, platelet, and C-reactive protein (CRP) levels of the patients were compared according to the length of hospitalization duration, survival, and clinical severity of COVID-19.
Results: Twenty-eight (%39.4) of the patients were male and 43 (%60.6) were female, and the mean age was 55.7±20.7 years. There was a significant difference between the groups of COVID-19 clinical severity in terms of age, fibrinogen, albumin, FAR, D-dimer, and CRP values (all p values were <0.001). Also, significantly higher fibrinogen, FAR, D-dimer, and CRP values were found in patients hospitalized longer, while the albumin level was lower in these patients (all p values were <0.001). FAR values were higher and albumin values were lower in non-surviving patients compared to surviving patients (p=0.025 and p<0.001, respectively).
Conclusion: FAR levels may be useful in predicting mortality risk in COVID-19 patients. In addition, it may be helpful and useful in determining the prognosis since it has higher levels as the severity of the disease and the length of hospital stay increase. |
| first_indexed | 2024-03-09T07:11:11Z |
| format | Article |
| id | doaj.art-36d8daa1a500475ca0b0b631b8374f29 |
| institution | Directory Open Access Journal |
| issn | 1307-671X |
| language | English |
| last_indexed | 2024-03-09T07:11:11Z |
| publishDate | 2022-08-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj.art-36d8daa1a500475ca0b0b631b8374f292023-12-03T09:06:38ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2022-08-0124217618110.18678/dtfd.110808697The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 PatientsDilcan Kotan0Saadet Sayan1Elif Sarıca Darol2Esen Çiçekli3Sakarya Üniversitesi Eğitim ve Araştırma HastanesiSakarya Üniversitesi Eğitim ve Araştırma HastanesiSakarya Üniversitesi Eğitim ve Araştırma HastanesiSakarya Akyazı Devlet HastanesiAim: Fibrinogen and albumin are proteins that play a role in inflammation. In this study, it was aimed to investigate the role of fibrinogen, albumin, and fibrinogen/albumin ratio (FAR) levels as markers of disease severity and prognosis in coronavirus disease 2019 (COVID-19) patients. Material and Methods: Seventy-one patients aged between 19 and 84 years diagnosed with COVID-19 who were hospitalized in Sakarya University Training and Research Hospital, Neurology Department between March and May 2020 were analyzed retrospectively. Fibrinogen, albumin, FAR, D-dimer, platelet, and C-reactive protein (CRP) levels of the patients were compared according to the length of hospitalization duration, survival, and clinical severity of COVID-19. Results: Twenty-eight (%39.4) of the patients were male and 43 (%60.6) were female, and the mean age was 55.7±20.7 years. There was a significant difference between the groups of COVID-19 clinical severity in terms of age, fibrinogen, albumin, FAR, D-dimer, and CRP values (all p values were <0.001). Also, significantly higher fibrinogen, FAR, D-dimer, and CRP values were found in patients hospitalized longer, while the albumin level was lower in these patients (all p values were <0.001). FAR values were higher and albumin values were lower in non-surviving patients compared to surviving patients (p=0.025 and p<0.001, respectively). Conclusion: FAR levels may be useful in predicting mortality risk in COVID-19 patients. In addition, it may be helpful and useful in determining the prognosis since it has higher levels as the severity of the disease and the length of hospital stay increase.https://dergipark.org.tr/en/download/article-file/2393110fibrinogenalbuminfibrinogen/albumin ratiocovid-19covid-19fibrinojenalbuminfibrinojen/albumin |
| spellingShingle | Dilcan Kotan Saadet Sayan Elif Sarıca Darol Esen Çiçekli The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients Düzce Tıp Fakültesi Dergisi fibrinogen albumin fibrinogen/albumin ratio covid-19 covid-19 fibrinojen albumin fibrinojen/albumin |
| title | The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients |
| title_full | The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients |
| title_fullStr | The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients |
| title_full_unstemmed | The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients |
| title_short | The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients |
| title_sort | value of fibrinogen albumin ratio on prognosis of covid 19 patients |
| topic | fibrinogen albumin fibrinogen/albumin ratio covid-19 covid-19 fibrinojen albumin fibrinojen/albumin |
| url | https://dergipark.org.tr/en/download/article-file/2393110 |
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