NOTCH1 Aberrations in Chronic Lymphocytic Leukemia

NOTCH1 Aberrations in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is an incurable B-cell neoplasm characterized by highly variable clinical outcomes. In recent years, genomic and molecular studies revealed a remarkable heterogeneity in CLL, which mirrored the clinical diversity of this disease. These studies profoundly enhanced o...

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Bibliographic Details
Main Authors: Emanuela Rosati, Stefano Baldoni, Filomena De Falco, Beatrice Del Papa, Erica Dorillo, Chiara Rompietti, Elisa Albi, Franca Falzetti, Mauro Di Ianni, Paolo Sportoletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Oncology
Subjects:
NOTCH1
chronic lymphocytic leukemia
prognostic biomarker
targeted therapy
gene mutation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00229/full

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