IKCa channels control breast cancer metabolism including AMPK-driven autophagy
Abstract Ca2+-activated K+ channels of intermediate conductance (IK) are frequently overexpressed in breast cancer (BC) cells, while IK channel depletion reduces BC cell proliferation and tumorigenesis. This raises the question, of whether and mechanistically how IK activity interferes with the meta...
Main Authors: | Dominic Gross, Helmut Bischof, Selina Maier, Katharina Sporbeck, Andreas L. Birkenfeld, Roland Malli, Peter Ruth, Tassula Proikas-Cezanne, Robert Lukowski |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2022-10-01
|
Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-022-05329-z |
Similar Items
-
ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans
by: Zsuzsanna Takacs, et al.
Published: (2019-03-01) -
WIPI-Mediated Autophagy and Longevity
by: Mona Grimmel, et al.
Published: (2015-05-01) -
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
by: Katharina Sporbeck, et al.
Published: (2023-08-01) -
WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.
by: Proikas-Cezanne, T, et al.
Published: (2004) -
A "no-hybrids" screen for functional antagonizers of human p53 transactivator function: dominant negativity in fission yeast.
by: Waddell, S, et al.
Published: (2001)