Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease
Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension. Among several key components of RAS, angiotensin peptides, varying in amino...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1377218 |
| _version_ | 1797681364961591296 |
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| author | Misbah Hussain Fazli Rabbi Awan |
| author_facet | Misbah Hussain Fazli Rabbi Awan |
| author_sort | Misbah Hussain |
| collection | DOAJ |
| description | Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension. Among several key components of RAS, angiotensin peptides, varying in amino acid length and biological function, have important roles in preventing or promoting hypertension, cardiovascular diseases, stroke, vascular remodeling etc. These peptides are generated by the metabolism of inactive angiotensinogen or its derived peptides by hydrolyzing action of certain enzymes. Angiotensin II, angiotensin (1–12), angiotensin A and angiotensin III bind primarily to angiotensin II type 1 receptor and cause vasoconstriction, accumulation of inflammatory markers to sub-endothelial region of blood vessels and activate smooth muscle cell proliferation. Moreover, when bound to angiotensin II type 2 receptor, angiotensin II works as cardio-protective peptide and halt pathological cell signals. Other peptides like angiotensin (1–9), angiotensin (1–7), alamandine and angiotensin IV also help in protecting from cardiovascular diseases by binding to their respective receptors. |
| first_indexed | 2024-03-11T23:43:50Z |
| format | Article |
| id | doaj.art-36dd3a652444427ca5d5ca41259a971c |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:50Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-36dd3a652444427ca5d5ca41259a971c2023-09-19T15:19:26ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062018-05-0140434435210.1080/10641963.2017.13772181377218Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular diseaseMisbah Hussain0Fazli Rabbi Awan1National Institute for Biotechnology and Genetic Engineering (NIBGE)National Institute for Biotechnology and Genetic Engineering (NIBGE)Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension. Among several key components of RAS, angiotensin peptides, varying in amino acid length and biological function, have important roles in preventing or promoting hypertension, cardiovascular diseases, stroke, vascular remodeling etc. These peptides are generated by the metabolism of inactive angiotensinogen or its derived peptides by hydrolyzing action of certain enzymes. Angiotensin II, angiotensin (1–12), angiotensin A and angiotensin III bind primarily to angiotensin II type 1 receptor and cause vasoconstriction, accumulation of inflammatory markers to sub-endothelial region of blood vessels and activate smooth muscle cell proliferation. Moreover, when bound to angiotensin II type 2 receptor, angiotensin II works as cardio-protective peptide and halt pathological cell signals. Other peptides like angiotensin (1–9), angiotensin (1–7), alamandine and angiotensin IV also help in protecting from cardiovascular diseases by binding to their respective receptors.http://dx.doi.org/10.1080/10641963.2017.1377218rasangiotensinogencardiovascular diseasesangiotensin converting enzymeangiotensin receptors |
| spellingShingle | Misbah Hussain Fazli Rabbi Awan Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease Clinical and Experimental Hypertension ras angiotensinogen cardiovascular diseases angiotensin converting enzyme angiotensin receptors |
| title | Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease |
| title_full | Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease |
| title_fullStr | Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease |
| title_full_unstemmed | Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease |
| title_short | Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease |
| title_sort | hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease |
| topic | ras angiotensinogen cardiovascular diseases angiotensin converting enzyme angiotensin receptors |
| url | http://dx.doi.org/10.1080/10641963.2017.1377218 |
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