Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci

Abstract Background Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis. Methods DNA samples exacted from CD4+ T c...

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Bibliographic Details
Main Authors: Tianlu Li, Lourdes Ortiz-Fernández, Eduardo Andrés-León, Laura Ciudad, Biola M. Javierre, Elena López-Isac, Alfredo Guillén-Del-Castillo, Carmen Pilar Simeón-Aznar, Esteban Ballestar, Javier Martin
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Genome Medicine
Subjects:
Systemic sclerosis
DNA methylation
Epigenetics
Long-distance regulation
Hi-C
Genetic susceptibility variants
Online Access:http://link.springer.com/article/10.1186/s13073-020-00779-6

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