Does molecular scarring in psoriasis exist? A review of the literature
Plaque psoriasis is a chronic inflammatory dermatosis characterized by a tendency to recur in the same locations after discontinuation of treatment. The implementation of therapy with drugs targeting cytokines like interleukin (IL) 17A (IL-17A) and IL-23 has revolutionized the treatment of psoriasis...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-07-01
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| Series: | Advances in Dermatology and Allergology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Does-molecular-scarring-in-psoriasis-exist-A-review-of-the-literature,7,51052,1,1.html |
| _version_ | 1797692313254756352 |
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| author | Marta Kasprowicz-Furmańczyk Joanna Narbutt Adam Borzęcki Agnieszka Owczarczyk-Saczonek |
| author_facet | Marta Kasprowicz-Furmańczyk Joanna Narbutt Adam Borzęcki Agnieszka Owczarczyk-Saczonek |
| author_sort | Marta Kasprowicz-Furmańczyk |
| collection | DOAJ |
| description | Plaque psoriasis is a chronic inflammatory dermatosis characterized by a tendency to recur in the same locations after discontinuation of treatment. The implementation of therapy with drugs targeting cytokines like interleukin (IL) 17A (IL-17A) and IL-23 has revolutionized the treatment of psoriasis and enabled the achievement of skin without lesions. However, despite the clinical resolution of psoriatic eruptions, cells that maintain the local memory of the disease remain in the dermis and epidermis, constituting a kind of molecular scar. The cells responsible for maintaining memory in the skin of patients and influencing the rapid relapse of the disease after the triggering factor are primarily tissue resident memory T cells (TRM), but it seems that regulatory T lymphocytes (Treg), dendritic cells (DC), and Langerhans cells (LC) may also play an important role in this process. We reviewed the literature to explain the concept of molecular scarring in psoriasis, and to assess the effect of various therapies on immune memory. |
| first_indexed | 2024-03-12T02:26:49Z |
| format | Article |
| id | doaj.art-36de2010e4d44e12b26daab35e637183 |
| institution | Directory Open Access Journal |
| issn | 1642-395X 2299-0046 |
| language | English |
| last_indexed | 2024-03-12T02:26:49Z |
| publishDate | 2023-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Advances in Dermatology and Allergology |
| spelling | doaj.art-36de2010e4d44e12b26daab35e6371832023-09-05T11:52:29ZengTermedia Publishing HouseAdvances in Dermatology and Allergology1642-395X2299-00462023-07-0140447348010.5114/ada.2023.12932251052Does molecular scarring in psoriasis exist? A review of the literatureMarta Kasprowicz-FurmańczykJoanna NarbuttAdam BorzęckiAgnieszka Owczarczyk-SaczonekPlaque psoriasis is a chronic inflammatory dermatosis characterized by a tendency to recur in the same locations after discontinuation of treatment. The implementation of therapy with drugs targeting cytokines like interleukin (IL) 17A (IL-17A) and IL-23 has revolutionized the treatment of psoriasis and enabled the achievement of skin without lesions. However, despite the clinical resolution of psoriatic eruptions, cells that maintain the local memory of the disease remain in the dermis and epidermis, constituting a kind of molecular scar. The cells responsible for maintaining memory in the skin of patients and influencing the rapid relapse of the disease after the triggering factor are primarily tissue resident memory T cells (TRM), but it seems that regulatory T lymphocytes (Treg), dendritic cells (DC), and Langerhans cells (LC) may also play an important role in this process. We reviewed the literature to explain the concept of molecular scarring in psoriasis, and to assess the effect of various therapies on immune memory.https://www.termedia.pl/Does-molecular-scarring-in-psoriasis-exist-A-review-of-the-literature,7,51052,1,1.htmltissue resident memory t cells molecular scar regulatory t lymphocytes dendritic cells langerhans cells |
| spellingShingle | Marta Kasprowicz-Furmańczyk Joanna Narbutt Adam Borzęcki Agnieszka Owczarczyk-Saczonek Does molecular scarring in psoriasis exist? A review of the literature Advances in Dermatology and Allergology tissue resident memory t cells molecular scar regulatory t lymphocytes dendritic cells langerhans cells |
| title | Does molecular scarring in psoriasis exist? A review of the literature |
| title_full | Does molecular scarring in psoriasis exist? A review of the literature |
| title_fullStr | Does molecular scarring in psoriasis exist? A review of the literature |
| title_full_unstemmed | Does molecular scarring in psoriasis exist? A review of the literature |
| title_short | Does molecular scarring in psoriasis exist? A review of the literature |
| title_sort | does molecular scarring in psoriasis exist a review of the literature |
| topic | tissue resident memory t cells molecular scar regulatory t lymphocytes dendritic cells langerhans cells |
| url | https://www.termedia.pl/Does-molecular-scarring-in-psoriasis-exist-A-review-of-the-literature,7,51052,1,1.html |
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