Apolipoprotein C3-Rich Low-Density Lipoprotein Induces Endothelial Cell Senescence via FBXO31 and Its Inhibition by Sesamol In Vitro and In Vivo

Apolipoprotein C3-Rich Low-Density Lipoprotein Induces Endothelial Cell Senescence via FBXO31 and Its Inhibition by Sesamol In Vitro and In Vivo

Premature endothelial senescence decreases the atheroprotective capacity of the arterial endothelium. Apolipoprotein C3 (ApoC3) delays the catabolism of triglyceride-rich particles and plays a critical role in atherosclerosis progression. FBXO31 is required for the intracellular response to DNA dama...

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Bibliographic Details
Main Authors: Ping-Hsuan Tsai, Li-Zhen Chen, Kuo-Feng Tseng, Fang-Yu Chen, Ming-Yi Shen
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
apolipoprotein C3-rich LDL
atherosclerosis
FBXO31
premature endothelial senescence
sesamol
Online Access:https://www.mdpi.com/2227-9059/10/4/854

Internet

https://www.mdpi.com/2227-9059/10/4/854

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