A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case Report
Leiomyomas are benign tumours of smooth muscle origin and can occur in any part of the body with adrenal gland being an uncommon site. Ganglioneuromas of adrenal gland are benign neural crest-derived tumours. Both of these tumours are usually detected incidentally. Hereby, the authors report an un...
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JCDR Research and Publications Private Limited
2023-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/18132/61297_CE[Ra1]_F(IS)_PF1(KA_SHU)_PFA(KA_KM)_PN(KM).pdf |
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| author | M Anjana KR Anila Anitha Mathews Abinaya R Nadarajan Siva Ranjith |
| author_facet | M Anjana KR Anila Anitha Mathews Abinaya R Nadarajan Siva Ranjith |
| author_sort | M Anjana |
| collection | DOAJ |
| description | Leiomyomas are benign tumours of smooth muscle origin and can occur in any part of the body with adrenal gland being an
uncommon site. Ganglioneuromas of adrenal gland are benign neural crest-derived tumours. Both of these tumours are usually
detected incidentally. Hereby, the authors report an unusual case of a 31-year-old woman, who presented with paroxysmal attacks
of headache, palpitations and flushing pointing towards a hormone secreting adrenal tumour. However, functional adrenal markers
were normal. Radiological investigations revealed 8×3 cm heterogeneously enhancing left suprarenal mass with calcification and
extension to left renal vein. Patient underwent left nephrectomy and adrenalectomy with a high clinical suspicion of malignancy
because of tumour extension to the renal vein. The histopathological examination revealed a leiomyoma arising in a background of
ganglioneuroma which was later on confirmed using immunohistochemistry. Authors have presented the present case because of
atypical presentation as a hormone secreting adrenal tumour with radiological features of malignancy and the unique histomorphology
of the combined occurrence of leiomyoma and ganglioneuromatous area in the adrenal gland. To the best of author’s knowledge,
this is the first case report of such an occurrence in the adrenal gland.
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| first_indexed | 2024-03-13T00:23:00Z |
| format | Article |
| id | doaj.art-36e414cbf6aa457c8cccd47c9c29bb2e |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-13T00:23:00Z |
| publishDate | 2023-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-36e414cbf6aa457c8cccd47c9c29bb2e2023-07-11T11:33:13ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-07-01177010310.7860/JCDR/2023/61297.18132A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case ReportM Anjana0KR Anila1Anitha Mathews2Abinaya R Nadarajan3Siva Ranjith4Senior Resident, Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.Associate Professor, Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.Additional Professor, Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.Resident, Department of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.Assistant Professor, Department of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.Leiomyomas are benign tumours of smooth muscle origin and can occur in any part of the body with adrenal gland being an uncommon site. Ganglioneuromas of adrenal gland are benign neural crest-derived tumours. Both of these tumours are usually detected incidentally. Hereby, the authors report an unusual case of a 31-year-old woman, who presented with paroxysmal attacks of headache, palpitations and flushing pointing towards a hormone secreting adrenal tumour. However, functional adrenal markers were normal. Radiological investigations revealed 8×3 cm heterogeneously enhancing left suprarenal mass with calcification and extension to left renal vein. Patient underwent left nephrectomy and adrenalectomy with a high clinical suspicion of malignancy because of tumour extension to the renal vein. The histopathological examination revealed a leiomyoma arising in a background of ganglioneuroma which was later on confirmed using immunohistochemistry. Authors have presented the present case because of atypical presentation as a hormone secreting adrenal tumour with radiological features of malignancy and the unique histomorphology of the combined occurrence of leiomyoma and ganglioneuromatous area in the adrenal gland. To the best of author’s knowledge, this is the first case report of such an occurrence in the adrenal gland. https://www.jcdr.net/articles/PDF/18132/61297_CE[Ra1]_F(IS)_PF1(KA_SHU)_PFA(KA_KM)_PN(KM).pdfbenign tumourneural crest-derivedsmooth muscle tumoursuprarenal mass |
| spellingShingle | M Anjana KR Anila Anitha Mathews Abinaya R Nadarajan Siva Ranjith A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case Report Journal of Clinical and Diagnostic Research benign tumour neural crest-derived smooth muscle tumour suprarenal mass |
| title | A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case Report |
| title_full | A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case Report |
| title_fullStr | A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case Report |
| title_full_unstemmed | A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case Report |
| title_short | A Rare Presentation of Adrenal Leiomyoma Arising in a Ganglioneuroma: A Case Report |
| title_sort | rare presentation of adrenal leiomyoma arising in a ganglioneuroma a case report |
| topic | benign tumour neural crest-derived smooth muscle tumour suprarenal mass |
| url | https://www.jcdr.net/articles/PDF/18132/61297_CE[Ra1]_F(IS)_PF1(KA_SHU)_PFA(KA_KM)_PN(KM).pdf |
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