Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men
Abstract Possible interactions of the neuropeptide oxytocin and the sex hormone estradiol may contribute to previously observed sex-specific effects of oxytocin on resting-state functional connectivity (rsFC) of the amygdala and hippocampus. Therefore, we used a placebo-controlled, randomized, paral...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-29754-y |
| _version_ | 1797864892354527232 |
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| author | Marie Coenjaerts Berina Adrovic Isabelle Trimborn Alexandra Philipsen René Hurlemann Dirk Scheele |
| author_facet | Marie Coenjaerts Berina Adrovic Isabelle Trimborn Alexandra Philipsen René Hurlemann Dirk Scheele |
| author_sort | Marie Coenjaerts |
| collection | DOAJ |
| description | Abstract Possible interactions of the neuropeptide oxytocin and the sex hormone estradiol may contribute to previously observed sex-specific effects of oxytocin on resting-state functional connectivity (rsFC) of the amygdala and hippocampus. Therefore, we used a placebo-controlled, randomized, parallel-group functional magnetic resonance imaging study design and measured amygdala and hippocampus rsFC in healthy men (n = 116) and free-cycling women (n = 111), who received estradiol gel (2 mg) or placebo before the intranasal administration of oxytocin (24 IU) or placebo. Our results reveal significant interaction effects of sex and treatments on rsFC of the amygdala and hippocampus in a seed-to-voxel analysis. In men, both oxytocin and estradiol significantly decreased rsFC between the left amygdala and the right and left lingual gyrus, the right calcarine fissure, and the right superior parietal gyrus compared to placebo, while the combined treatment produced a significant increase in rsFC. In women, the single treatments significantly increased the rsFC between the right hippocampus and the left anterior cingulate gyrus, whereas the combined treatment had the opposite effect. Collectively, our study indicates that exogenous oxytocin and estradiol have different region-specific effects on rsFC in women and men and that the combined treatment may produce antagonistic effects. |
| first_indexed | 2024-04-09T23:00:28Z |
| format | Article |
| id | doaj.art-36e6780cec0b415bb7ab3a72bab3db10 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:00:28Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-36e6780cec0b415bb7ab3a72bab3db102023-03-22T11:01:30ZengNature PortfolioScientific Reports2045-23222023-02-0113111010.1038/s41598-023-29754-yEffects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and menMarie Coenjaerts0Berina Adrovic1Isabelle Trimborn2Alexandra Philipsen3René Hurlemann4Dirk Scheele5Research Section Medical Psychology, Department of Psychiatry and Psychotherapy, University Hospital BonnResearch Section Medical Psychology, Department of Psychiatry and Psychotherapy, University Hospital BonnResearch Section Medical Psychology, Department of Psychiatry and Psychotherapy, University Hospital BonnDepartment of Psychiatry and Psychotherapy, University Hospital BonnDepartment of Psychiatry, School of Medicine & Health Sciences, University of OldenburgDepartment of Social Neuroscience, Faculty of Psychology, Ruhr-University BochumAbstract Possible interactions of the neuropeptide oxytocin and the sex hormone estradiol may contribute to previously observed sex-specific effects of oxytocin on resting-state functional connectivity (rsFC) of the amygdala and hippocampus. Therefore, we used a placebo-controlled, randomized, parallel-group functional magnetic resonance imaging study design and measured amygdala and hippocampus rsFC in healthy men (n = 116) and free-cycling women (n = 111), who received estradiol gel (2 mg) or placebo before the intranasal administration of oxytocin (24 IU) or placebo. Our results reveal significant interaction effects of sex and treatments on rsFC of the amygdala and hippocampus in a seed-to-voxel analysis. In men, both oxytocin and estradiol significantly decreased rsFC between the left amygdala and the right and left lingual gyrus, the right calcarine fissure, and the right superior parietal gyrus compared to placebo, while the combined treatment produced a significant increase in rsFC. In women, the single treatments significantly increased the rsFC between the right hippocampus and the left anterior cingulate gyrus, whereas the combined treatment had the opposite effect. Collectively, our study indicates that exogenous oxytocin and estradiol have different region-specific effects on rsFC in women and men and that the combined treatment may produce antagonistic effects.https://doi.org/10.1038/s41598-023-29754-y |
| spellingShingle | Marie Coenjaerts Berina Adrovic Isabelle Trimborn Alexandra Philipsen René Hurlemann Dirk Scheele Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men Scientific Reports |
| title | Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men |
| title_full | Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men |
| title_fullStr | Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men |
| title_full_unstemmed | Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men |
| title_short | Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men |
| title_sort | effects of exogenous oxytocin and estradiol on resting state functional connectivity in women and men |
| url | https://doi.org/10.1038/s41598-023-29754-y |
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