Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance

The occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t(8;21) subtype. Therefore, it is important to u...

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Main Authors: Caixia Han, Xuefeng Gao, Yonghui Li, Juan Zhang, Erna Yang, Li Zhang, Li Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.579881/full
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author Caixia Han
Xuefeng Gao
Yonghui Li
Juan Zhang
Erna Yang
Li Zhang
Li Yu
author_facet Caixia Han
Xuefeng Gao
Yonghui Li
Juan Zhang
Erna Yang
Li Zhang
Li Yu
author_sort Caixia Han
collection DOAJ
description The occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t(8;21) subtype. Therefore, it is important to understand how cohesin mutations contribute to leukemogenesis. However, the fundamental understanding of cohesin mutation in clonal expansion and myeloid transformation in hematopoietic cells remains ambiguous. Previous studies briefly introduced the cohesin mutation in AML; however, an in-depth summary of mutations in AML was not provided, and the correlation between cohesin and AML1-ETO in t (8;21) AML was also not analyzed. By summarizing the major findings regarding the cohesin mutation in AML, this review aims to define the characteristics of the cohesin complex mutation, identify its relationships with co-occurring gene mutations, assess its roles in clonal evolution, and discuss its potential for the prognosis of AML. In particular, we focus on the function of cohesin mutations in RUNX1-RUNX1T1 fusion.
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spelling doaj.art-36e69d711275466eb878eeed0f9480452022-12-21T18:27:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011110.3389/fonc.2021.579881579881Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical SignificanceCaixia HanXuefeng GaoYonghui LiJuan ZhangErna YangLi ZhangLi YuThe occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t(8;21) subtype. Therefore, it is important to understand how cohesin mutations contribute to leukemogenesis. However, the fundamental understanding of cohesin mutation in clonal expansion and myeloid transformation in hematopoietic cells remains ambiguous. Previous studies briefly introduced the cohesin mutation in AML; however, an in-depth summary of mutations in AML was not provided, and the correlation between cohesin and AML1-ETO in t (8;21) AML was also not analyzed. By summarizing the major findings regarding the cohesin mutation in AML, this review aims to define the characteristics of the cohesin complex mutation, identify its relationships with co-occurring gene mutations, assess its roles in clonal evolution, and discuss its potential for the prognosis of AML. In particular, we focus on the function of cohesin mutations in RUNX1-RUNX1T1 fusion.https://www.frontiersin.org/articles/10.3389/fonc.2021.579881/fullcohesin mutationacute myeloid leukemiaAML1-ETOhematopoietic stem and progenitor cellsleukemogenesis
spellingShingle Caixia Han
Xuefeng Gao
Yonghui Li
Juan Zhang
Erna Yang
Li Zhang
Li Yu
Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
Frontiers in Oncology
cohesin mutation
acute myeloid leukemia
AML1-ETO
hematopoietic stem and progenitor cells
leukemogenesis
title Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
title_full Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
title_fullStr Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
title_full_unstemmed Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
title_short Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance
title_sort characteristics of cohesin mutation in acute myeloid leukemia and its clinical significance
topic cohesin mutation
acute myeloid leukemia
AML1-ETO
hematopoietic stem and progenitor cells
leukemogenesis
url https://www.frontiersin.org/articles/10.3389/fonc.2021.579881/full
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