Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain
Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation of the trigeminal nerve or its branches, with both peripheral and central nervous system dysfunction contributing to the disorder. Trigeminal pain conditions present with diagnostic and therapeutic challenges to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/6/3/91 |
| _version_ | 1818275198335451136 |
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| author | Pawan Bista Wendy L. Imlach |
| author_facet | Pawan Bista Wendy L. Imlach |
| author_sort | Pawan Bista |
| collection | DOAJ |
| description | Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation of the trigeminal nerve or its branches, with both peripheral and central nervous system dysfunction contributing to the disorder. Trigeminal pain conditions present with diagnostic and therapeutic challenges to healthcare providers and often require multiple therapeutic approaches for pain reduction. This review will provide the overview of pathophysiology in peripheral and central nociceptive circuits that are involved in neuropathic pain conditions involving the trigeminal nerve and the current therapeutics that are used to treat these disorders. Recent advances in treatment of trigeminal pain, including novel therapeutics that target ion channels and receptors, gene therapy and monoclonal antibodies that have shown great promise in preclinical studies and clinical trials will also be described. |
| first_indexed | 2024-12-12T22:25:56Z |
| format | Article |
| id | doaj.art-36e9a0eaeb7d4901a80b97e80e7186a7 |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-12-12T22:25:56Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-36e9a0eaeb7d4901a80b97e80e7186a72022-12-22T00:09:45ZengMDPI AGMedicines2305-63202019-08-01639110.3390/medicines6030091medicines6030091Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic PainPawan Bista0Wendy L. Imlach1Department of Physiology & Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, AustraliaDepartment of Physiology & Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, AustraliaTrigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation of the trigeminal nerve or its branches, with both peripheral and central nervous system dysfunction contributing to the disorder. Trigeminal pain conditions present with diagnostic and therapeutic challenges to healthcare providers and often require multiple therapeutic approaches for pain reduction. This review will provide the overview of pathophysiology in peripheral and central nociceptive circuits that are involved in neuropathic pain conditions involving the trigeminal nerve and the current therapeutics that are used to treat these disorders. Recent advances in treatment of trigeminal pain, including novel therapeutics that target ion channels and receptors, gene therapy and monoclonal antibodies that have shown great promise in preclinical studies and clinical trials will also be described.https://www.mdpi.com/2305-6320/6/3/91Trigeminal neuropathic paintrigeminal nervenociceptionpathological painnociceptive circuitsorofacial paindental painmigrainetrigeminal spinal caudalistrigeminal ganglion |
| spellingShingle | Pawan Bista Wendy L. Imlach Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain Medicines Trigeminal neuropathic pain trigeminal nerve nociception pathological pain nociceptive circuits orofacial pain dental pain migraine trigeminal spinal caudalis trigeminal ganglion |
| title | Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain |
| title_full | Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain |
| title_fullStr | Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain |
| title_full_unstemmed | Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain |
| title_short | Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain |
| title_sort | pathological mechanisms and therapeutic targets for trigeminal neuropathic pain |
| topic | Trigeminal neuropathic pain trigeminal nerve nociception pathological pain nociceptive circuits orofacial pain dental pain migraine trigeminal spinal caudalis trigeminal ganglion |
| url | https://www.mdpi.com/2305-6320/6/3/91 |
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