An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia
Abstract Background Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementatio...
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| Format: | Article |
| Language: | English |
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BMC
2017-04-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12936-017-1795-y |
| _version_ | 1828486366052220928 |
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| author | Raffaele Dell’Acqua Claudia Fabrizio Francesco Di Gennaro Sergio Lo Caputo Annalisa Saracino Michela Menegon Mariangela L’Episcopia Carlo Severini Laura Monno Francesco Castelli Gioacchino Angarano |
| author_facet | Raffaele Dell’Acqua Claudia Fabrizio Francesco Di Gennaro Sergio Lo Caputo Annalisa Saracino Michela Menegon Mariangela L’Episcopia Carlo Severini Laura Monno Francesco Castelli Gioacchino Angarano |
| author_sort | Raffaele Dell’Acqua |
| collection | DOAJ |
| description | Abstract Background Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementation of health prevention measures. Case report A complex case of imported malaria caused by Plasmodium vivax/P. falciparum isolates in a patient who was not taking chemoprophylaxis while he was travelling in Cambodia is reported in this article. After failures of artemisinin-based and both oral and intravenous quinine-based regimens, a multidrug resistant P. falciparum was detected. The patient was successfully treated with atovaquone–proguanil. Conclusions This experience highlights the importance of a careful management that should be based not only on the most up-to-date guidelines, but also on the awareness of a rapidly evolving scenario. |
| first_indexed | 2024-12-11T09:31:48Z |
| format | Article |
| id | doaj.art-36e9aec2f5244c9f81abcab33face1be |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-11T09:31:48Z |
| publishDate | 2017-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-36e9aec2f5244c9f81abcab33face1be2022-12-22T01:12:59ZengBMCMalaria Journal1475-28752017-04-011611410.1186/s12936-017-1795-yAn intricate case of multidrug resistant Plasmodium falciparum isolate imported from CambodiaRaffaele Dell’Acqua0Claudia Fabrizio1Francesco Di Gennaro2Sergio Lo Caputo3Annalisa Saracino4Michela Menegon5Mariangela L’Episcopia6Carlo Severini7Laura Monno8Francesco Castelli9Gioacchino Angarano10Clinic of Infectious Diseases, Università degli Studi di Bari Aldo MoroClinic of Infectious Diseases, Università degli Studi di Bari Aldo MoroClinic of Infectious Diseases, Università degli Studi di Bari Aldo MoroClinic of Infectious Diseases, Università degli Studi di Bari Aldo MoroClinic of Infectious Diseases, Università degli Studi di Bari Aldo MoroDepartment of Infectious Diseases, Istituto Superiore di SanitàDepartment of Infectious Diseases, Istituto Superiore di SanitàDepartment of Infectious Diseases, Istituto Superiore di SanitàClinic of Infectious Diseases, Università degli Studi di Bari Aldo MoroUniversity Department of Infectious and Tropical Diseases, Azienda Ospedaliera Spedali Civili di BresciaClinic of Infectious Diseases, Università degli Studi di Bari Aldo MoroAbstract Background Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementation of health prevention measures. Case report A complex case of imported malaria caused by Plasmodium vivax/P. falciparum isolates in a patient who was not taking chemoprophylaxis while he was travelling in Cambodia is reported in this article. After failures of artemisinin-based and both oral and intravenous quinine-based regimens, a multidrug resistant P. falciparum was detected. The patient was successfully treated with atovaquone–proguanil. Conclusions This experience highlights the importance of a careful management that should be based not only on the most up-to-date guidelines, but also on the awareness of a rapidly evolving scenario.http://link.springer.com/article/10.1186/s12936-017-1795-yMalaria, VivaxMalaria, FalciparumMalariaDrug resistanceMultipleAntimalarials |
| spellingShingle | Raffaele Dell’Acqua Claudia Fabrizio Francesco Di Gennaro Sergio Lo Caputo Annalisa Saracino Michela Menegon Mariangela L’Episcopia Carlo Severini Laura Monno Francesco Castelli Gioacchino Angarano An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia Malaria Journal Malaria, Vivax Malaria, Falciparum Malaria Drug resistance Multiple Antimalarials |
| title | An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia |
| title_full | An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia |
| title_fullStr | An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia |
| title_full_unstemmed | An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia |
| title_short | An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia |
| title_sort | intricate case of multidrug resistant plasmodium falciparum isolate imported from cambodia |
| topic | Malaria, Vivax Malaria, Falciparum Malaria Drug resistance Multiple Antimalarials |
| url | http://link.springer.com/article/10.1186/s12936-017-1795-y |
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