Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine
Fikadu Ejeta Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, EthiopiaCorrespondence: Fikadu Ejeta Tel +251910136034Email fikaduejeta@gmail.comAbstract: Nanomedicine drug delivery systems hold great poten...
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| Format: | Article |
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Dove Medical Press
2021-09-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/recent-advances-of-microfluidic-platforms-for-controlled-drug-delivery-peer-reviewed-fulltext-article-DDDT |
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| author | Ejeta F |
| author_facet | Ejeta F |
| author_sort | Ejeta F |
| collection | DOAJ |
| description | Fikadu Ejeta Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, EthiopiaCorrespondence: Fikadu Ejeta Tel +251910136034Email fikaduejeta@gmail.comAbstract: Nanomedicine drug delivery systems hold great potential for the therapy of many diseases, especially cancer. However, the controlled drug delivery systems of nanomedicine bring many challenges to clinical practice. These difficulties can be attributed to the high batch-to-batch variations and insufficient production rate of traditional preparation methods, as well as a lack of technology for fast screening of nanoparticulate drug delivery structures with high correlation to in vivo tests. These problems may be addressed through microfluidic technology. Microfluidics, for example, can not only produce nanoparticles in a well-controlled, reproducible, and high-throughput manner, but it can also continuously create three-dimensional environments to mimic physiological and/or pathological processes. This overview gives a top-level view of the microfluidic devices advanced to put together nanoparticulate drug delivery systems, including drug nanosuspensions, polymer nanoparticles, polyplexes, structured nanoparticles and therapeutic nanoparticles. Additionally, highlighting the current advances of microfluidic systems in fabricating the more and more practical fashions of the in vitro milieus for fast screening of nanoparticles was reviewed. Overall, microfluidic technology provides a promising technique to boost the scientific delivery of nanomedicine and nanoparticulate drug delivery systems. Nonetheless, digital microfluidics with droplets and liquid marbles is the answer to the problems of cumbersome external structures, in addition to the rather big pattern volume. As the latest work is best at the proof-of-idea of liquid-marble-primarily based on totally virtual microfluidics, computerized structures for developing liquid marble, and the controlled manipulation of liquid marble, including coalescence and splitting, are areas of interest for bringing this platform toward realistic use.Keywords: microfluidic, nanomedicine, controlled drug delivery, nanocarriers |
| first_indexed | 2024-12-18T01:11:10Z |
| format | Article |
| id | doaj.art-36e9f69d38714c008b73f1574cf72296 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-18T01:11:10Z |
| publishDate | 2021-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-36e9f69d38714c008b73f1574cf722962022-12-21T21:26:06ZengDove Medical PressDrug Design, Development and Therapy1177-88812021-09-01Volume 153881389168707Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in NanomedicineEjeta FFikadu Ejeta Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, EthiopiaCorrespondence: Fikadu Ejeta Tel +251910136034Email fikaduejeta@gmail.comAbstract: Nanomedicine drug delivery systems hold great potential for the therapy of many diseases, especially cancer. However, the controlled drug delivery systems of nanomedicine bring many challenges to clinical practice. These difficulties can be attributed to the high batch-to-batch variations and insufficient production rate of traditional preparation methods, as well as a lack of technology for fast screening of nanoparticulate drug delivery structures with high correlation to in vivo tests. These problems may be addressed through microfluidic technology. Microfluidics, for example, can not only produce nanoparticles in a well-controlled, reproducible, and high-throughput manner, but it can also continuously create three-dimensional environments to mimic physiological and/or pathological processes. This overview gives a top-level view of the microfluidic devices advanced to put together nanoparticulate drug delivery systems, including drug nanosuspensions, polymer nanoparticles, polyplexes, structured nanoparticles and therapeutic nanoparticles. Additionally, highlighting the current advances of microfluidic systems in fabricating the more and more practical fashions of the in vitro milieus for fast screening of nanoparticles was reviewed. Overall, microfluidic technology provides a promising technique to boost the scientific delivery of nanomedicine and nanoparticulate drug delivery systems. Nonetheless, digital microfluidics with droplets and liquid marbles is the answer to the problems of cumbersome external structures, in addition to the rather big pattern volume. As the latest work is best at the proof-of-idea of liquid-marble-primarily based on totally virtual microfluidics, computerized structures for developing liquid marble, and the controlled manipulation of liquid marble, including coalescence and splitting, are areas of interest for bringing this platform toward realistic use.Keywords: microfluidic, nanomedicine, controlled drug delivery, nanocarriershttps://www.dovepress.com/recent-advances-of-microfluidic-platforms-for-controlled-drug-delivery-peer-reviewed-fulltext-article-DDDTmicrofluidicnanomedicinecontrolled drug deliverynanocarriers |
| spellingShingle | Ejeta F Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine Drug Design, Development and Therapy microfluidic nanomedicine controlled drug delivery nanocarriers |
| title | Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine |
| title_full | Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine |
| title_fullStr | Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine |
| title_full_unstemmed | Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine |
| title_short | Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine |
| title_sort | recent advances of microfluidic platforms for controlled drug delivery in nanomedicine |
| topic | microfluidic nanomedicine controlled drug delivery nanocarriers |
| url | https://www.dovepress.com/recent-advances-of-microfluidic-platforms-for-controlled-drug-delivery-peer-reviewed-fulltext-article-DDDT |
| work_keys_str_mv | AT ejetaf recentadvancesofmicrofluidicplatformsforcontrolleddrugdeliveryinnanomedicine |