The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and Consequences
During the maturation of intestinal epithelial cells along the crypt/surface axis, a multitude of acid/base transporters are differentially expressed in their apical and basolateral membranes, enabling processes of electrolyte, macromolecule, nutrient, acid/base and fluid secretion, and absorption....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.618135/full |
| _version_ | 1818640972897058816 |
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| author | Mahdi Amiri Ursula E. Seidler Katerina Nikolovska |
| author_facet | Mahdi Amiri Ursula E. Seidler Katerina Nikolovska |
| author_sort | Mahdi Amiri |
| collection | DOAJ |
| description | During the maturation of intestinal epithelial cells along the crypt/surface axis, a multitude of acid/base transporters are differentially expressed in their apical and basolateral membranes, enabling processes of electrolyte, macromolecule, nutrient, acid/base and fluid secretion, and absorption. An intracellular pH (pHi)-gradient is generated along the epithelial crypt/surface axis, either as a consequence of the sum of the ion transport activities or as a distinctly regulated entity. While the role of pHi on proliferation, migration, and tumorigenesis has been explored in cancer cells for some time, emerging evidence suggests an important role of the pHi in the intestinal stem cells (ISCs) proliferative rate under physiological conditions. The present review highlights the current state of knowledge about the potential regulatory role of pHi on intestinal proliferation and differentiation. |
| first_indexed | 2024-12-16T23:19:46Z |
| format | Article |
| id | doaj.art-36eae5500c5b4899b2efd5fbbae157a8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T23:19:46Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-36eae5500c5b4899b2efd5fbbae157a82022-12-21T22:12:12ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01910.3389/fcell.2021.618135618135The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and ConsequencesMahdi AmiriUrsula E. SeidlerKaterina NikolovskaDuring the maturation of intestinal epithelial cells along the crypt/surface axis, a multitude of acid/base transporters are differentially expressed in their apical and basolateral membranes, enabling processes of electrolyte, macromolecule, nutrient, acid/base and fluid secretion, and absorption. An intracellular pH (pHi)-gradient is generated along the epithelial crypt/surface axis, either as a consequence of the sum of the ion transport activities or as a distinctly regulated entity. While the role of pHi on proliferation, migration, and tumorigenesis has been explored in cancer cells for some time, emerging evidence suggests an important role of the pHi in the intestinal stem cells (ISCs) proliferative rate under physiological conditions. The present review highlights the current state of knowledge about the potential regulatory role of pHi on intestinal proliferation and differentiation.https://www.frontiersin.org/articles/10.3389/fcell.2021.618135/fullintracellular pHepithelial ion transportproliferationsignaling pathwaysintestinal epithelial cells |
| spellingShingle | Mahdi Amiri Ursula E. Seidler Katerina Nikolovska The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and Consequences Frontiers in Cell and Developmental Biology intracellular pH epithelial ion transport proliferation signaling pathways intestinal epithelial cells |
| title | The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and Consequences |
| title_full | The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and Consequences |
| title_fullStr | The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and Consequences |
| title_full_unstemmed | The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and Consequences |
| title_short | The Role of pHi in Intestinal Epithelial Proliferation–Transport Mechanisms, Regulatory Pathways, and Consequences |
| title_sort | role of phi in intestinal epithelial proliferation transport mechanisms regulatory pathways and consequences |
| topic | intracellular pH epithelial ion transport proliferation signaling pathways intestinal epithelial cells |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.618135/full |
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