Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancer
Paul Aridgides,1 Tamara Nsouli,1 Rishabh Chaudhari,1 Russell Kincaid,1 Paula F Rosenbaum,2 Sean Tanny,1 Michael Mix,1 Jeffrey Bogart1 1Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; 2Department of Public Health and Preventive Medicine, SUNY Upstate Medica...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-11-01
|
| Series: | Lung Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinical-outcomes-following-advanced-respiratory-motion-management-res-peer-reviewed-article-LCTT |
| _version_ | 1819130060978782208 |
|---|---|
| author | Aridgides P Nsouli T Chaudhari R Kincaid R Rosenbaum PF Tanny S Mix M Bogart J |
| author_facet | Aridgides P Nsouli T Chaudhari R Kincaid R Rosenbaum PF Tanny S Mix M Bogart J |
| author_sort | Aridgides P |
| collection | DOAJ |
| description | Paul Aridgides,1 Tamara Nsouli,1 Rishabh Chaudhari,1 Russell Kincaid,1 Paula F Rosenbaum,2 Sean Tanny,1 Michael Mix,1 Jeffrey Bogart1 1Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; 2Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA Purpose: To report the outcomes of stereotactic body radiation therapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) according to respiratory motion management method. Methods: Patients with stage I NSCLC who received SBRT from 2007 to 2015 were reviewed. Computed tomography (CT) simulation with four-dimensional CT was performed for respiratory motion assessment. Tumor motion >1 cm in the craniocaudal direction was selectively treated with advanced respiratory management: either respiratory gating to a pre-specified portion of the respiratory cycle or dynamic tracking of an implanted fiducial marker. Comparisons were made with internal target volume approach, which treated all phases of respiratory motion. Results: Of 297 patients treated with SBRT at our institution, 51 underwent advanced respiratory management (48 with respiratory gating and three with tumor tracking) and 246 underwent all-phase treatment. Groups were similarly balanced with regard to mean age (P=0.242), tumor size (P=0.315), and histology (P=0.715). Tumor location in the lower lung lobes, as compared to middle or upper lobes, was more common in those treated with advanced respiratory management (78.4%) compared to all-phase treatment (25.6%, P<0.0001). There were 17 local recurrences in the treated lesions. Kaplan–Meier analyses showed that there were no differences with regard to mean time to local failure (91.5 vs 98.8 months, P=0.56), mean time to any failure (73.2 vs 78.7 months, P=0.73), or median overall survival (43.3 vs 45.5 months, P=0.56) between patients who underwent advanced respiratory motion management and all-phase treatment.Conclusion: SBRT with advanced respiratory management (the majority with respiratory gating) showed similar efficacy to all-phase treatment approach for stage I NSCLC. Keywords: SBRT, respiratory gating, lung cancer, radiation therapy, medically inoperable, stage I |
| first_indexed | 2024-12-22T08:53:37Z |
| format | Article |
| id | doaj.art-36ec38cf3b8c4d608ce88283fe166449 |
| institution | Directory Open Access Journal |
| issn | 1179-2728 |
| language | English |
| last_indexed | 2024-12-22T08:53:37Z |
| publishDate | 2018-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Lung Cancer: Targets and Therapy |
| spelling | doaj.art-36ec38cf3b8c4d608ce88283fe1664492022-12-21T18:31:55ZengDove Medical PressLung Cancer: Targets and Therapy1179-27282018-11-01Volume 910311042045Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancerAridgides PNsouli TChaudhari RKincaid RRosenbaum PFTanny SMix MBogart JPaul Aridgides,1 Tamara Nsouli,1 Rishabh Chaudhari,1 Russell Kincaid,1 Paula F Rosenbaum,2 Sean Tanny,1 Michael Mix,1 Jeffrey Bogart1 1Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; 2Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA Purpose: To report the outcomes of stereotactic body radiation therapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) according to respiratory motion management method. Methods: Patients with stage I NSCLC who received SBRT from 2007 to 2015 were reviewed. Computed tomography (CT) simulation with four-dimensional CT was performed for respiratory motion assessment. Tumor motion >1 cm in the craniocaudal direction was selectively treated with advanced respiratory management: either respiratory gating to a pre-specified portion of the respiratory cycle or dynamic tracking of an implanted fiducial marker. Comparisons were made with internal target volume approach, which treated all phases of respiratory motion. Results: Of 297 patients treated with SBRT at our institution, 51 underwent advanced respiratory management (48 with respiratory gating and three with tumor tracking) and 246 underwent all-phase treatment. Groups were similarly balanced with regard to mean age (P=0.242), tumor size (P=0.315), and histology (P=0.715). Tumor location in the lower lung lobes, as compared to middle or upper lobes, was more common in those treated with advanced respiratory management (78.4%) compared to all-phase treatment (25.6%, P<0.0001). There were 17 local recurrences in the treated lesions. Kaplan–Meier analyses showed that there were no differences with regard to mean time to local failure (91.5 vs 98.8 months, P=0.56), mean time to any failure (73.2 vs 78.7 months, P=0.73), or median overall survival (43.3 vs 45.5 months, P=0.56) between patients who underwent advanced respiratory motion management and all-phase treatment.Conclusion: SBRT with advanced respiratory management (the majority with respiratory gating) showed similar efficacy to all-phase treatment approach for stage I NSCLC. Keywords: SBRT, respiratory gating, lung cancer, radiation therapy, medically inoperable, stage Ihttps://www.dovepress.com/clinical-outcomes-following-advanced-respiratory-motion-management-res-peer-reviewed-article-LCTTSBRTrespiratory gatinglung cancerradiotherapymedically inoperablestage I |
| spellingShingle | Aridgides P Nsouli T Chaudhari R Kincaid R Rosenbaum PF Tanny S Mix M Bogart J Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancer Lung Cancer: Targets and Therapy SBRT respiratory gating lung cancer radiotherapy medically inoperable stage I |
| title | Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancer |
| title_full | Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancer |
| title_fullStr | Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancer |
| title_full_unstemmed | Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancer |
| title_short | Clinical outcomes following advanced respiratory motion management (respiratory gating or dynamic tumor tracking) with stereotactic body radiation therapy for stage I non-small-cell lung cancer |
| title_sort | clinical outcomes following advanced respiratory motion management respiratory gating or dynamic tumor tracking with stereotactic body radiation therapy for stage i non small cell lung cancer |
| topic | SBRT respiratory gating lung cancer radiotherapy medically inoperable stage I |
| url | https://www.dovepress.com/clinical-outcomes-following-advanced-respiratory-motion-management-res-peer-reviewed-article-LCTT |
| work_keys_str_mv | AT aridgidesp clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer AT nsoulit clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer AT chaudharir clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer AT kincaidr clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer AT rosenbaumpf clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer AT tannys clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer AT mixm clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer AT bogartj clinicaloutcomesfollowingadvancedrespiratorymotionmanagementrespiratorygatingordynamictumortrackingwithstereotacticbodyradiationtherapyforstageinonsmallcelllungcancer |