Serotonin and the regulation of mammalian energy balance.
Maintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in under...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-03-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00036/full |
| _version_ | 1818882343525416960 |
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| author | Michael H Donovan Laurence H Tecott |
| author_facet | Michael H Donovan Laurence H Tecott |
| author_sort | Michael H Donovan |
| collection | DOAJ |
| description | Maintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in understanding how central nervous system serotonin systems acting through a diverse array of serotonin receptors impact feeding behavior and metabolism. Particular attention has been paid to mechanisms through which serotonin impacts energy balance pathways within the hypothalamus. How upstream factors relevant to energy balance regulate the release of hypothalamic serotonin is less clear, but work addressing this issue is underway. Generally, investigation into the central serotonergic regulation of energy balance has had a predominantly hypothalamocentric focus, yet nonhypothalamic structures that have been implicated in energy balance regulation also receive serotonergic innervation and express multiple subtypes of serotonin receptors. Moreover, there is a growing appreciation of the diverse mechanisms through which peripheral serotonin impacts energy balance regulation. Clearly, the serotonergic regulation of energy balance is a field characterized by both rapid advances and by an extensive and diverse set of central and peripheral mechanisms yet to be delineated. |
| first_indexed | 2024-12-19T15:16:15Z |
| format | Article |
| id | doaj.art-36edf29bff0741d3a09cf9d16782dc9c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T15:16:15Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-36edf29bff0741d3a09cf9d16782dc9c2022-12-21T20:16:08ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2013-03-01710.3389/fnins.2013.0003640186Serotonin and the regulation of mammalian energy balance.Michael H Donovan0Laurence H Tecott1University of California San FranciscoUniversity of California San FranciscoMaintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in understanding how central nervous system serotonin systems acting through a diverse array of serotonin receptors impact feeding behavior and metabolism. Particular attention has been paid to mechanisms through which serotonin impacts energy balance pathways within the hypothalamus. How upstream factors relevant to energy balance regulate the release of hypothalamic serotonin is less clear, but work addressing this issue is underway. Generally, investigation into the central serotonergic regulation of energy balance has had a predominantly hypothalamocentric focus, yet nonhypothalamic structures that have been implicated in energy balance regulation also receive serotonergic innervation and express multiple subtypes of serotonin receptors. Moreover, there is a growing appreciation of the diverse mechanisms through which peripheral serotonin impacts energy balance regulation. Clearly, the serotonergic regulation of energy balance is a field characterized by both rapid advances and by an extensive and diverse set of central and peripheral mechanisms yet to be delineated.http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00036/fullArcuate NucleusFeeding BehaviorGhrelinHypothalamusInsulinLeptin |
| spellingShingle | Michael H Donovan Laurence H Tecott Serotonin and the regulation of mammalian energy balance. Frontiers in Neuroscience Arcuate Nucleus Feeding Behavior Ghrelin Hypothalamus Insulin Leptin |
| title | Serotonin and the regulation of mammalian energy balance. |
| title_full | Serotonin and the regulation of mammalian energy balance. |
| title_fullStr | Serotonin and the regulation of mammalian energy balance. |
| title_full_unstemmed | Serotonin and the regulation of mammalian energy balance. |
| title_short | Serotonin and the regulation of mammalian energy balance. |
| title_sort | serotonin and the regulation of mammalian energy balance |
| topic | Arcuate Nucleus Feeding Behavior Ghrelin Hypothalamus Insulin Leptin |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00036/full |
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