A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)
<p>Abstract</p> <p>Background</p> <p>Recent research has emphasized that the human circadian rhythm system is differentially sensitive to short wavelength light. Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-08-01
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| Series: | BMC Psychiatry |
| Online Access: | http://www.biomedcentral.com/1471-244X/7/38 |
| _version_ | 1818562852673290240 |
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| author | Telner John Horn Edward Ruiter Martine J Meesters Ybe Tam Edwin M Michalak Erin E Weinstein Andrea J Desan Paul H Iskandar Hani Boivin Diane B Lam Raymond W |
| author_facet | Telner John Horn Edward Ruiter Martine J Meesters Ybe Tam Edwin M Michalak Erin E Weinstein Andrea J Desan Paul H Iskandar Hani Boivin Diane B Lam Raymond W |
| author_sort | Telner John |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent research has emphasized that the human circadian rhythm system is differentially sensitive to short wavelength light. Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD).</p> <p>Methods</p> <p>The efficacy of a LED light therapy device in the treatment of SAD was tested in a randomized, double-blind, placebo-controlled, multi-center trial. Participants aged 18 to 65 with SAD (DSM-IV major depression with seasonal pattern) were seen at Baseline and Randomization visits separated by 1 week, and after 1, 2, 3 and 4 weeks of treatment. Hamilton Depression Rating Scale scores (SIGH-SAD) were obtained at each visit. Participants with SIGH-SAD of 20 or greater at Baseline and Randomization visits were randomized to active or control treatment: exposure to the Litebook LED treatment device (The Litebook Company Ltd., Alberta, Canada) which delivers 1,350 lux white light (with spectral emission peaks at 464 nm and 564 nm) at a distance of 20 inches or to an inactivated negative ion generator at a distance of 20 inches, for 30 minutes a day upon awakening and prior to 8 A.M.</p> <p>Results</p> <p>Of the 26 participants randomized, 23 completed the trial. Mean group SIGH-SAD scores did not differ significantly at randomization. At trial end, the proportions of participants in remission (SIGH-SAD less than 9) were significantly greater (Fisher's exact test), and SIGH-SAD scores, as percent individual score at randomization, were significantly lower (t-test), with active treatment than with control, both in an intent-to-treat analysis and an observed cases analysis. A longitudinal repeated measures ANOVA analysis of SIGH-SAD scores also indicated a significant interaction of time and treatment, showing superiority of the Litebook over the placebo condition.</p> <p>Conclusion</p> <p>The results of this pilot study support the hypothesis that light therapy with the Litebook is an effective treatment for SAD.</p> <p>Trial registration</p> <p>Clinicaltrials.gov: NCT00139997</p> |
| first_indexed | 2024-12-14T01:09:10Z |
| format | Article |
| id | doaj.art-36ee91c4cab14fcaa16dbe65a3886dfe |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-14T01:09:10Z |
| publishDate | 2007-08-01 |
| publisher | BMC |
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| series | BMC Psychiatry |
| spelling | doaj.art-36ee91c4cab14fcaa16dbe65a3886dfe2022-12-21T23:22:49ZengBMCBMC Psychiatry1471-244X2007-08-01713810.1186/1471-244X-7-38A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)Telner JohnHorn EdwardRuiter Martine JMeesters YbeTam Edwin MMichalak Erin EWeinstein Andrea JDesan Paul HIskandar HaniBoivin Diane BLam Raymond W<p>Abstract</p> <p>Background</p> <p>Recent research has emphasized that the human circadian rhythm system is differentially sensitive to short wavelength light. Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD).</p> <p>Methods</p> <p>The efficacy of a LED light therapy device in the treatment of SAD was tested in a randomized, double-blind, placebo-controlled, multi-center trial. Participants aged 18 to 65 with SAD (DSM-IV major depression with seasonal pattern) were seen at Baseline and Randomization visits separated by 1 week, and after 1, 2, 3 and 4 weeks of treatment. Hamilton Depression Rating Scale scores (SIGH-SAD) were obtained at each visit. Participants with SIGH-SAD of 20 or greater at Baseline and Randomization visits were randomized to active or control treatment: exposure to the Litebook LED treatment device (The Litebook Company Ltd., Alberta, Canada) which delivers 1,350 lux white light (with spectral emission peaks at 464 nm and 564 nm) at a distance of 20 inches or to an inactivated negative ion generator at a distance of 20 inches, for 30 minutes a day upon awakening and prior to 8 A.M.</p> <p>Results</p> <p>Of the 26 participants randomized, 23 completed the trial. Mean group SIGH-SAD scores did not differ significantly at randomization. At trial end, the proportions of participants in remission (SIGH-SAD less than 9) were significantly greater (Fisher's exact test), and SIGH-SAD scores, as percent individual score at randomization, were significantly lower (t-test), with active treatment than with control, both in an intent-to-treat analysis and an observed cases analysis. A longitudinal repeated measures ANOVA analysis of SIGH-SAD scores also indicated a significant interaction of time and treatment, showing superiority of the Litebook over the placebo condition.</p> <p>Conclusion</p> <p>The results of this pilot study support the hypothesis that light therapy with the Litebook is an effective treatment for SAD.</p> <p>Trial registration</p> <p>Clinicaltrials.gov: NCT00139997</p>http://www.biomedcentral.com/1471-244X/7/38 |
| spellingShingle | Telner John Horn Edward Ruiter Martine J Meesters Ybe Tam Edwin M Michalak Erin E Weinstein Andrea J Desan Paul H Iskandar Hani Boivin Diane B Lam Raymond W A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) BMC Psychiatry |
| title | A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) |
| title_full | A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) |
| title_fullStr | A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) |
| title_full_unstemmed | A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) |
| title_short | A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) |
| title_sort | controlled trial of the litebook light emitting diode led light therapy device for treatment of seasonal affective disorder sad |
| url | http://www.biomedcentral.com/1471-244X/7/38 |
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