Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior Myocarditis
Myocarditis has in rare cases been associated with COVID-19 infection and has emerged as a possible rare side effect of vaccination with anti-COVID-19 messenger RNA vaccines. However, little is known about possible COVID-19 infection- and/or vaccination-related myocarditis relapse in patients with p...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/12/1742 |
| _version_ | 1827573410353381376 |
|---|---|
| author | Anna Baritussio Andrea Silvio Giordani Cristina Basso Cristina Vicenzetto Giulia Lorenzoni Matteo Gasparin Sabino Iliceto Bruno Scarpa Dario Gregori Renzo Marcolongo Alida Linda Patrizia Caforio |
| author_facet | Anna Baritussio Andrea Silvio Giordani Cristina Basso Cristina Vicenzetto Giulia Lorenzoni Matteo Gasparin Sabino Iliceto Bruno Scarpa Dario Gregori Renzo Marcolongo Alida Linda Patrizia Caforio |
| author_sort | Anna Baritussio |
| collection | DOAJ |
| description | Myocarditis has in rare cases been associated with COVID-19 infection and has emerged as a possible rare side effect of vaccination with anti-COVID-19 messenger RNA vaccines. However, little is known about possible COVID-19 infection- and/or vaccination-related myocarditis relapse in patients with previous clinically suspected or biopsy-proven myocarditis. Myocarditis may relapse, particularly in females with immune-mediated/autoimmune features and a predisposing immunogenetic background. We aimed to assess the prevalence of myocarditis relapse during the COVID-19 outbreak and following COVID-19 vaccination in a cohort of patients with prior myocarditis. We included in the analysis myocarditis patients on active follow-up, for whom COVID-19 infection and vaccination statuses were known, and collected data on clinical, laboratory and echocardiographic findings, and myocarditis relapse. We enrolled 409 patients, of whom 114 (28%) reported COVID-19 infection and 347 (85%) completed the vaccination scheme. Only one patient, having COVID-19 infection before the vaccination campaign started, was admitted to hospital because of pneumonia; the remaining patients had an uneventful COVID-19 infection course, with only mild symptoms. No myocarditis relapse was recorded following COVID-19 infection or vaccination. Moreover, the frequency of new myocarditis cases following the COVID-19 outbreak was not different compared to the three-year period preceding the COVID-19 era. In conclusion, in our cohort of patients with prior myocarditis, both COVID-19 infection and vaccination were uneventful. |
| first_indexed | 2024-03-08T20:17:57Z |
| format | Article |
| id | doaj.art-36efec492d8b40d0bcb5d7dd81146fbb |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-08T20:17:57Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-36efec492d8b40d0bcb5d7dd81146fbb2023-12-22T14:46:51ZengMDPI AGVaccines2076-393X2023-11-011112174210.3390/vaccines11121742Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior MyocarditisAnna Baritussio0Andrea Silvio Giordani1Cristina Basso2Cristina Vicenzetto3Giulia Lorenzoni4Matteo Gasparin5Sabino Iliceto6Bruno Scarpa7Dario Gregori8Renzo Marcolongo9Alida Linda Patrizia Caforio10Cardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University Hospital, University of Padua, 35128 Padua, ItalyCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University Hospital, University of Padua, 35128 Padua, ItalyCardiac Pathology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, ItalyCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University Hospital, University of Padua, 35128 Padua, ItalyUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Statistical Sciences, University of Padua, 35121 Padua, ItalyCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University Hospital, University of Padua, 35128 Padua, ItalyDepartment of Statistical Sciences, University of Padua, 35121 Padua, ItalyUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University Hospital, University of Padua, 35128 Padua, ItalyCardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padua University Hospital, University of Padua, 35128 Padua, ItalyMyocarditis has in rare cases been associated with COVID-19 infection and has emerged as a possible rare side effect of vaccination with anti-COVID-19 messenger RNA vaccines. However, little is known about possible COVID-19 infection- and/or vaccination-related myocarditis relapse in patients with previous clinically suspected or biopsy-proven myocarditis. Myocarditis may relapse, particularly in females with immune-mediated/autoimmune features and a predisposing immunogenetic background. We aimed to assess the prevalence of myocarditis relapse during the COVID-19 outbreak and following COVID-19 vaccination in a cohort of patients with prior myocarditis. We included in the analysis myocarditis patients on active follow-up, for whom COVID-19 infection and vaccination statuses were known, and collected data on clinical, laboratory and echocardiographic findings, and myocarditis relapse. We enrolled 409 patients, of whom 114 (28%) reported COVID-19 infection and 347 (85%) completed the vaccination scheme. Only one patient, having COVID-19 infection before the vaccination campaign started, was admitted to hospital because of pneumonia; the remaining patients had an uneventful COVID-19 infection course, with only mild symptoms. No myocarditis relapse was recorded following COVID-19 infection or vaccination. Moreover, the frequency of new myocarditis cases following the COVID-19 outbreak was not different compared to the three-year period preceding the COVID-19 era. In conclusion, in our cohort of patients with prior myocarditis, both COVID-19 infection and vaccination were uneventful.https://www.mdpi.com/2076-393X/11/12/1742myocarditismyocarditis relapseCOVID-19 infectionCOVID-19 vaccination |
| spellingShingle | Anna Baritussio Andrea Silvio Giordani Cristina Basso Cristina Vicenzetto Giulia Lorenzoni Matteo Gasparin Sabino Iliceto Bruno Scarpa Dario Gregori Renzo Marcolongo Alida Linda Patrizia Caforio Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior Myocarditis Vaccines myocarditis myocarditis relapse COVID-19 infection COVID-19 vaccination |
| title | Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior Myocarditis |
| title_full | Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior Myocarditis |
| title_fullStr | Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior Myocarditis |
| title_full_unstemmed | Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior Myocarditis |
| title_short | Uneventful COVID-19 Infection and Vaccination in a Cohort of Patients with Prior Myocarditis |
| title_sort | uneventful covid 19 infection and vaccination in a cohort of patients with prior myocarditis |
| topic | myocarditis myocarditis relapse COVID-19 infection COVID-19 vaccination |
| url | https://www.mdpi.com/2076-393X/11/12/1742 |
| work_keys_str_mv | AT annabaritussio uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT andreasilviogiordani uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT cristinabasso uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT cristinavicenzetto uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT giulialorenzoni uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT matteogasparin uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT sabinoiliceto uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT brunoscarpa uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT dariogregori uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT renzomarcolongo uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis AT alidalindapatriziacaforio uneventfulcovid19infectionandvaccinationinacohortofpatientswithpriormyocarditis |