Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer

Background: Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma. Methods: Utilising 915 colon and...

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Main Authors: Kenji Fujiyoshi, Juha P. Väyrynen, Jennifer Borowsky, David J. Papke, Jr., Kota Arima, Koichiro Haruki, Junko Kishikawa, Naohiko Akimoto, Tomotaka Ugai, Mai Chan Lau, Simeng Gu, Shanshan Shi, Melissa Zhao, Annacarolina Fabiana Lucia Da Silva, Tyler S. Twombly, Hongmei Nan, Jeffrey A. Meyerhardt, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Charles S. Fuchs, Jochen K. Lennerz, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:EBioMedicine
Subjects:
adenocarcinoma
artificial intelligence, clinical outcomes
epithelial mesenchymal transition
host-tumour interaction
molecular pathological epidemiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302358

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http://www.sciencedirect.com/science/article/pii/S2352396420302358

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