Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients.
BACKGROUND:Anti-tuberculosis drug induced hepatotoxicity (ATDH) is a major adverse drug reaction associated for anti-tuberculosis therapy. The glutathione S-transferases (GST) plays a crucial role in the detoxification of hepatotoxic metabolites of anti-tuberculosis drugs.An association between GSTM...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4272297?pdf=render |
| _version_ | 1819048319934005248 |
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| author | Fang Liu An-xia Jiao Xi-rong Wu Wei Zhao Qing-qin Yin Hui Qi Wei-wei Jiao Jing Xiao Lin Sun Chen Shen Jian-ling Tian Dan Shen Evelyne Jacqz-Aigrain A-dong Shen |
| author_facet | Fang Liu An-xia Jiao Xi-rong Wu Wei Zhao Qing-qin Yin Hui Qi Wei-wei Jiao Jing Xiao Lin Sun Chen Shen Jian-ling Tian Dan Shen Evelyne Jacqz-Aigrain A-dong Shen |
| author_sort | Fang Liu |
| collection | DOAJ |
| description | BACKGROUND:Anti-tuberculosis drug induced hepatotoxicity (ATDH) is a major adverse drug reaction associated for anti-tuberculosis therapy. The glutathione S-transferases (GST) plays a crucial role in the detoxification of hepatotoxic metabolites of anti-tuberculosis drugs.An association between GSTM1/GSTT1 null mutations and increased risk of ATDH has been demonstrated in adults. Given the ethnic differences and developmental changes, our study aims to investigate the potential impacts of GSTM1/GSTT1 genotypes on the development of ATDH in Han Chinese children treated with anti-tuberculosis therapy. METHODS:Children receiving anti-tuberculosis therapy with or without evidence of ATDH were considered as the cases or controls, respectively. The GSTM1 and GSTT1 genotyping were performed using the polymerase chain reaction. RESULTS:One hundred sixty-three children (20 cases and 143 controls) with a mean age of 4.7 years (range: 2 months-14.1 years) were included. For the GSTM1, 14 (70.0%) cases and 96 (67.1%) controls had homozygous null mutations. For the GSTT1, 13 (65.0%) cases and 97 (67.8%) controls had homozygous null mutations. Neither the GSTM1, nor the GSTT1 polymorphism was significantly correlated with the occurrence of ATHD. CONCLUSION:Our results did not support the GSTM1 and GSTT1 polymorphisms as the predictors of ADTH in Chinese Han children treated with anti-tuberculosis drugs. An age-related association between pharmacogenetics and ATHD need to be confirmed in the further study. |
| first_indexed | 2024-12-21T11:14:23Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T11:14:23Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-36f0380247914b29b97ef30f6634fa712022-12-21T19:05:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11541010.1371/journal.pone.0115410Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients.Fang LiuAn-xia JiaoXi-rong WuWei ZhaoQing-qin YinHui QiWei-wei JiaoJing XiaoLin SunChen ShenJian-ling TianDan ShenEvelyne Jacqz-AigrainA-dong ShenBACKGROUND:Anti-tuberculosis drug induced hepatotoxicity (ATDH) is a major adverse drug reaction associated for anti-tuberculosis therapy. The glutathione S-transferases (GST) plays a crucial role in the detoxification of hepatotoxic metabolites of anti-tuberculosis drugs.An association between GSTM1/GSTT1 null mutations and increased risk of ATDH has been demonstrated in adults. Given the ethnic differences and developmental changes, our study aims to investigate the potential impacts of GSTM1/GSTT1 genotypes on the development of ATDH in Han Chinese children treated with anti-tuberculosis therapy. METHODS:Children receiving anti-tuberculosis therapy with or without evidence of ATDH were considered as the cases or controls, respectively. The GSTM1 and GSTT1 genotyping were performed using the polymerase chain reaction. RESULTS:One hundred sixty-three children (20 cases and 143 controls) with a mean age of 4.7 years (range: 2 months-14.1 years) were included. For the GSTM1, 14 (70.0%) cases and 96 (67.1%) controls had homozygous null mutations. For the GSTT1, 13 (65.0%) cases and 97 (67.8%) controls had homozygous null mutations. Neither the GSTM1, nor the GSTT1 polymorphism was significantly correlated with the occurrence of ATHD. CONCLUSION:Our results did not support the GSTM1 and GSTT1 polymorphisms as the predictors of ADTH in Chinese Han children treated with anti-tuberculosis drugs. An age-related association between pharmacogenetics and ATHD need to be confirmed in the further study.http://europepmc.org/articles/PMC4272297?pdf=render |
| spellingShingle | Fang Liu An-xia Jiao Xi-rong Wu Wei Zhao Qing-qin Yin Hui Qi Wei-wei Jiao Jing Xiao Lin Sun Chen Shen Jian-ling Tian Dan Shen Evelyne Jacqz-Aigrain A-dong Shen Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients. PLoS ONE |
| title | Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients. |
| title_full | Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients. |
| title_fullStr | Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients. |
| title_full_unstemmed | Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients. |
| title_short | Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients. |
| title_sort | impact of glutathione s transferase m1 and t1 on anti tuberculosis drug induced hepatotoxicity in chinese pediatric patients |
| url | http://europepmc.org/articles/PMC4272297?pdf=render |
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