Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy
Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but excessive reactive oxygen species (ROS) generation and oxidative stress represent common denominators associated with adverse...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcvm.2020.00012/full |
| _version_ | 1818295942419316736 |
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| author | Nina Kaludercic Fabio Di Lisa Fabio Di Lisa |
| author_facet | Nina Kaludercic Fabio Di Lisa Fabio Di Lisa |
| author_sort | Nina Kaludercic |
| collection | DOAJ |
| description | Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but excessive reactive oxygen species (ROS) generation and oxidative stress represent common denominators associated with adverse tissue remodeling. Indeed, key processes underlying cardiac remodeling in diabetes are redox sensitive, including inflammation, organelle dysfunction, alteration in ion homeostasis, cardiomyocyte hypertrophy, apoptosis, fibrosis, and contractile dysfunction. Extensive experimental evidence supports the involvement of mitochondrial ROS formation in the alterations characterizing the diabetic heart. In this review we will outline the central role of mitochondrial ROS and alterations in the redox status contributing to the development of diabetic cardiomyopathy. We will discuss the role of different sources of ROS involved in this process, with a specific emphasis on mitochondrial ROS producing enzymes within cardiomyocytes. Finally, the therapeutic potential of pharmacological inhibitors of ROS sources within the mitochondria will be discussed. |
| first_indexed | 2024-12-13T03:55:39Z |
| format | Article |
| id | doaj.art-36f03c99410d4eaa8949a3fd4594561c |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-13T03:55:39Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-36f03c99410d4eaa8949a3fd4594561c2022-12-22T00:00:37ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2020-02-01710.3389/fcvm.2020.00012508901Mitochondrial ROS Formation in the Pathogenesis of Diabetic CardiomyopathyNina Kaludercic0Fabio Di Lisa1Fabio Di Lisa2Neuroscience Institute, National Research Council of Italy (CNR), Padua, ItalyNeuroscience Institute, National Research Council of Italy (CNR), Padua, ItalyDepartment of Biomedical Sciences, University of Padua, Padua, ItalyDiabetic cardiomyopathy is a result of diabetes-induced changes in the structure and function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but excessive reactive oxygen species (ROS) generation and oxidative stress represent common denominators associated with adverse tissue remodeling. Indeed, key processes underlying cardiac remodeling in diabetes are redox sensitive, including inflammation, organelle dysfunction, alteration in ion homeostasis, cardiomyocyte hypertrophy, apoptosis, fibrosis, and contractile dysfunction. Extensive experimental evidence supports the involvement of mitochondrial ROS formation in the alterations characterizing the diabetic heart. In this review we will outline the central role of mitochondrial ROS and alterations in the redox status contributing to the development of diabetic cardiomyopathy. We will discuss the role of different sources of ROS involved in this process, with a specific emphasis on mitochondrial ROS producing enzymes within cardiomyocytes. Finally, the therapeutic potential of pharmacological inhibitors of ROS sources within the mitochondria will be discussed.https://www.frontiersin.org/article/10.3389/fcvm.2020.00012/fulldiabetic cardiomyopathyreactive oxygen speciesmitochondriaoxidative stressdiabetic complication |
| spellingShingle | Nina Kaludercic Fabio Di Lisa Fabio Di Lisa Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy Frontiers in Cardiovascular Medicine diabetic cardiomyopathy reactive oxygen species mitochondria oxidative stress diabetic complication |
| title | Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy |
| title_full | Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy |
| title_fullStr | Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy |
| title_full_unstemmed | Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy |
| title_short | Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy |
| title_sort | mitochondrial ros formation in the pathogenesis of diabetic cardiomyopathy |
| topic | diabetic cardiomyopathy reactive oxygen species mitochondria oxidative stress diabetic complication |
| url | https://www.frontiersin.org/article/10.3389/fcvm.2020.00012/full |
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