The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies
Interest in the role of coagulation and fibrinolysis in the nervous system was active in several laboratories dating back before cloning of the functional thrombin receptor in 1991. As one of those, our attention was initially on thrombin and plasminogen activators in synapse formation and eliminati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/11/1558 |
| _version_ | 1797511062494380032 |
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| author | Barry W. Festoff Chris Dockendorff |
| author_facet | Barry W. Festoff Chris Dockendorff |
| author_sort | Barry W. Festoff |
| collection | DOAJ |
| description | Interest in the role of coagulation and fibrinolysis in the nervous system was active in several laboratories dating back before cloning of the functional thrombin receptor in 1991. As one of those, our attention was initially on thrombin and plasminogen activators in synapse formation and elimination in the neuromuscular system, with orientation towards diseases such as amyotrophic lateral sclerosis (ALS) and how clotting and fibrinolytic pathways fit into its pathogenesis. This perspective is on neuro-thromboinflammation, emphasizing this emerging concept from studies and reports over more than three decades. It underscores how it may lead to novel therapeutic approaches to treat the ravages of neurotrauma and neurodegenerative diseases, with a focus on PAR1, ALS, and parmodulins. |
| first_indexed | 2024-03-10T05:41:01Z |
| format | Article |
| id | doaj.art-36f1bcfe095544b190983c03e84c4a0e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T05:41:01Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-36f1bcfe095544b190983c03e84c4a0e2023-11-22T22:32:56ZengMDPI AGBiomolecules2218-273X2021-10-011111155810.3390/biom11111558The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting TherapiesBarry W. Festoff0Chris Dockendorff1PHLOGISTIX LLC, Department of Neurology, University of Kansas Medical School, Kansas City, MO 64108, USAFunction Therapeutics LLC, Milwaukee, WI 53202, USAInterest in the role of coagulation and fibrinolysis in the nervous system was active in several laboratories dating back before cloning of the functional thrombin receptor in 1991. As one of those, our attention was initially on thrombin and plasminogen activators in synapse formation and elimination in the neuromuscular system, with orientation towards diseases such as amyotrophic lateral sclerosis (ALS) and how clotting and fibrinolytic pathways fit into its pathogenesis. This perspective is on neuro-thromboinflammation, emphasizing this emerging concept from studies and reports over more than three decades. It underscores how it may lead to novel therapeutic approaches to treat the ravages of neurotrauma and neurodegenerative diseases, with a focus on PAR1, ALS, and parmodulins.https://www.mdpi.com/2218-273X/11/11/1558neurodegenerationneurotraumaALSinflammationthromboinflammationneuro-thromboinflammation |
| spellingShingle | Barry W. Festoff Chris Dockendorff The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies Biomolecules neurodegeneration neurotrauma ALS inflammation thromboinflammation neuro-thromboinflammation |
| title | The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies |
| title_full | The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies |
| title_fullStr | The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies |
| title_full_unstemmed | The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies |
| title_short | The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies |
| title_sort | evolving concept of neuro thromboinflammation for neurodegenerative disorders and neurotrauma a rationale for par1 targeting therapies |
| topic | neurodegeneration neurotrauma ALS inflammation thromboinflammation neuro-thromboinflammation |
| url | https://www.mdpi.com/2218-273X/11/11/1558 |
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