Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for Keratoconus
Background: The aim of this study was to analyze the long-term topographic and refractive outcomes of corneal cross-linking (CXL) in keratoconus. Methods: We used a retrospective observational study of patients with keratoconus who underwent CXL with a minimum follow-up of 5 years. Patients’ refract...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/7/1950 |
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| author | Maryam Eslami Farhad Ghaseminejad Paul J. Dubord Sonia N. Yeung Alfonso Iovieno |
| author_facet | Maryam Eslami Farhad Ghaseminejad Paul J. Dubord Sonia N. Yeung Alfonso Iovieno |
| author_sort | Maryam Eslami |
| collection | DOAJ |
| description | Background: The aim of this study was to analyze the long-term topographic and refractive outcomes of corneal cross-linking (CXL) in keratoconus. Methods: We used a retrospective observational study of patients with keratoconus who underwent CXL with a minimum follow-up of 5 years. Patients’ refractive and topography data (corrected distance visual acuity, sphere, cylinder, average and maximum keratometry, and corneal aberrations) were collected. Results: A total of 112 patients/150 eyes (mean age: 33.2 ± 10.7 years; range: 13–61) were included. The mean follow-up was 5.87 ± 1.35 years (range: 5–10). At the last follow-up visit, an improvement in CDVA, spherical and cylindrical refraction, average and steepest keratometry, and corneal aberrations were observed (<i>p</i> < 0.05), with the exception of trefoil. At the last visit, 49 (34.8%) and 31 (22.0%) eyes had an improvement beyond 1D in their spherical and cylindrical power, respectively, and 43 (28.7%) eyes had a flattening of their steepest keratometry. Progressive improvement over time was observed for spherical refraction; max and mean-K; as well as corneal RMS, total, high, coma, and spherical aberrations (<i>p</i> < 0.05). More severe disease at the baseline correlated with an improvement in corneal aberrations over time. Conclusions: In addition to a progressive improvement in refractive and keratometric indices, corneal aberrations also demonstrate a steady decline with long-term follow-up after CXL, which was more pronounced in more severe patients. |
| first_indexed | 2024-03-09T11:42:18Z |
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| id | doaj.art-36f21742cd154d8ab1c66997d6b68553 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-09T11:42:18Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-36f21742cd154d8ab1c66997d6b685532023-11-30T23:29:06ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01117195010.3390/jcm11071950Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for KeratoconusMaryam Eslami0Farhad Ghaseminejad1Paul J. Dubord2Sonia N. Yeung3Alfonso Iovieno4Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z0A6, CanadaDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z0A6, CanadaDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z0A6, CanadaDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z0A6, CanadaDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z0A6, CanadaBackground: The aim of this study was to analyze the long-term topographic and refractive outcomes of corneal cross-linking (CXL) in keratoconus. Methods: We used a retrospective observational study of patients with keratoconus who underwent CXL with a minimum follow-up of 5 years. Patients’ refractive and topography data (corrected distance visual acuity, sphere, cylinder, average and maximum keratometry, and corneal aberrations) were collected. Results: A total of 112 patients/150 eyes (mean age: 33.2 ± 10.7 years; range: 13–61) were included. The mean follow-up was 5.87 ± 1.35 years (range: 5–10). At the last follow-up visit, an improvement in CDVA, spherical and cylindrical refraction, average and steepest keratometry, and corneal aberrations were observed (<i>p</i> < 0.05), with the exception of trefoil. At the last visit, 49 (34.8%) and 31 (22.0%) eyes had an improvement beyond 1D in their spherical and cylindrical power, respectively, and 43 (28.7%) eyes had a flattening of their steepest keratometry. Progressive improvement over time was observed for spherical refraction; max and mean-K; as well as corneal RMS, total, high, coma, and spherical aberrations (<i>p</i> < 0.05). More severe disease at the baseline correlated with an improvement in corneal aberrations over time. Conclusions: In addition to a progressive improvement in refractive and keratometric indices, corneal aberrations also demonstrate a steady decline with long-term follow-up after CXL, which was more pronounced in more severe patients.https://www.mdpi.com/2077-0383/11/7/1950corneal crosslinkingkeratoconuscorneal aberrations |
| spellingShingle | Maryam Eslami Farhad Ghaseminejad Paul J. Dubord Sonia N. Yeung Alfonso Iovieno Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for Keratoconus Journal of Clinical Medicine corneal crosslinking keratoconus corneal aberrations |
| title | Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for Keratoconus |
| title_full | Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for Keratoconus |
| title_fullStr | Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for Keratoconus |
| title_full_unstemmed | Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for Keratoconus |
| title_short | Delayed Topographical and Refractive Changes Following Corneal Cross-Linking for Keratoconus |
| title_sort | delayed topographical and refractive changes following corneal cross linking for keratoconus |
| topic | corneal crosslinking keratoconus corneal aberrations |
| url | https://www.mdpi.com/2077-0383/11/7/1950 |
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