It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching
This study was to explore whether postponing frozen embryo transfers (FET) after oocyte pickup (OPU) improves clinical and neonatal outcomes. From May 2018 to Dec 2020, a total of 1109 patients underwent their first OPU cycles adopting a non-selective freeze-all policy were included in this retrospe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.971616/full |
| _version_ | 1798004561543168000 |
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| author | Mengxia Ji Bihui Jin Xiaoyan Guo Ruifang Wu Yunqing Jiang Ling Zhang Jing Shu |
| author_facet | Mengxia Ji Bihui Jin Xiaoyan Guo Ruifang Wu Yunqing Jiang Ling Zhang Jing Shu |
| author_sort | Mengxia Ji |
| collection | DOAJ |
| description | This study was to explore whether postponing frozen embryo transfers (FET) after oocyte pickup (OPU) improves clinical and neonatal outcomes. From May 2018 to Dec 2020, a total of 1109 patients underwent their first OPU cycles adopting a non-selective freeze-all policy were included in this retrospective cohort study. In the immediate group (n=219), patients underwent FET in the first menstrual cycle after OPU, and patients in the postponed group (n=890) waited for more than 1 menstrual cycle after OPU to perform FET. A propensity score matching (PSM) model was used to evaluate the clinical outcomes and neonatal outcomes between the two groups. There were 209 patients in the immediate group and 499 patients in the postponed one after PSM. Patients waited for a significantly shorter period for FET in the immediate group (30.74 ± 3.85 days) compared with the postponed group (80.39 ± 26.25 days, P<0.01). The clinical pregnancy rate (CPR) and live birth rate (LBR) in the immediate group were 58.4% and 48.3%, respectively, which were comparable to those of the postponed one (58.1%, 49.7%, P > 0.05). No statistical significance was found in the average birth weight (3088.82 ± 565.35 g vs 3038.64 ± 625.78 g, P > 0.05) and height (49.08 ± 1.87 cm vs 49.30 ± 2.52 cm) of neonates between the two groups. The gender ratio, the incidence of macrosomia and low birth weight did not differ significantly between the two groups. In conclusion, postponing FET does not improve clinical and neonatal outcomes. If patients have no contraindications, FETs should be carried out immediately after OPU. |
| first_indexed | 2024-04-11T12:25:35Z |
| format | Article |
| id | doaj.art-36f28bb3334a404fa15c553dbd8327a6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T12:25:35Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-36f28bb3334a404fa15c553dbd8327a62022-12-22T04:23:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.971616971616It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matchingMengxia JiBihui JinXiaoyan GuoRuifang WuYunqing JiangLing ZhangJing ShuThis study was to explore whether postponing frozen embryo transfers (FET) after oocyte pickup (OPU) improves clinical and neonatal outcomes. From May 2018 to Dec 2020, a total of 1109 patients underwent their first OPU cycles adopting a non-selective freeze-all policy were included in this retrospective cohort study. In the immediate group (n=219), patients underwent FET in the first menstrual cycle after OPU, and patients in the postponed group (n=890) waited for more than 1 menstrual cycle after OPU to perform FET. A propensity score matching (PSM) model was used to evaluate the clinical outcomes and neonatal outcomes between the two groups. There were 209 patients in the immediate group and 499 patients in the postponed one after PSM. Patients waited for a significantly shorter period for FET in the immediate group (30.74 ± 3.85 days) compared with the postponed group (80.39 ± 26.25 days, P<0.01). The clinical pregnancy rate (CPR) and live birth rate (LBR) in the immediate group were 58.4% and 48.3%, respectively, which were comparable to those of the postponed one (58.1%, 49.7%, P > 0.05). No statistical significance was found in the average birth weight (3088.82 ± 565.35 g vs 3038.64 ± 625.78 g, P > 0.05) and height (49.08 ± 1.87 cm vs 49.30 ± 2.52 cm) of neonates between the two groups. The gender ratio, the incidence of macrosomia and low birth weight did not differ significantly between the two groups. In conclusion, postponing FET does not improve clinical and neonatal outcomes. If patients have no contraindications, FETs should be carried out immediately after OPU.https://www.frontiersin.org/articles/10.3389/fendo.2022.971616/fullFrozen embryo transferfreeze-allin vitro fertilizationlive birthpropensity score |
| spellingShingle | Mengxia Ji Bihui Jin Xiaoyan Guo Ruifang Wu Yunqing Jiang Ling Zhang Jing Shu It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching Frontiers in Endocrinology Frozen embryo transfer freeze-all in vitro fertilization live birth propensity score |
| title | It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching |
| title_full | It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching |
| title_fullStr | It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching |
| title_full_unstemmed | It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching |
| title_short | It is not worth postponing frozen embryo transfers after oocyte pickup: A retrospective cohort study based on propensity score matching |
| title_sort | it is not worth postponing frozen embryo transfers after oocyte pickup a retrospective cohort study based on propensity score matching |
| topic | Frozen embryo transfer freeze-all in vitro fertilization live birth propensity score |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.971616/full |
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