Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae
Shiwei Liang,1,2,* Huijun Cao,1,* Fei Ying,1 Chenchen Zhang2 1Centre for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, People’s Republic o...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/report-of-a-fatal-purulent-pericarditis-case-caused-by-st11-k64-carbap-peer-reviewed-fulltext-article-IDR |
| _version_ | 1817998126257012736 |
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| author | Liang S Cao H Ying F Zhang C |
| author_facet | Liang S Cao H Ying F Zhang C |
| author_sort | Liang S |
| collection | DOAJ |
| description | Shiwei Liang,1,2,* Huijun Cao,1,* Fei Ying,1 Chenchen Zhang2 1Centre for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Ying, Tel +86 13985509788, Email feiying@gmc.edu.cnAbstract: The report describes a 44-year-old female patient who died of the rare acute purulent pericarditis caused by Klebsiella pneumoniae (KP). The genomic analysis revealed an extensively drug-resistant ST11-K64 KP strain from five isolates (blood cultures, urine, ascites, pericardial effusion, and sputum). Several high virulence (hv) and carbapenem-resistant (CR) genes were identified in the pericardial effuse isolate. The isolates showed low resistance to healthy human serum. This study highlights the potential lethality of CR-hvKP infections in patients suffering from underlying comorbidities such as diabetes mellitus and chronic ailments.Keywords: purulent pericarditis, Klebsiella pneumoniae, carbapenem-resistance, hypervirulence, ST11, K64 |
| first_indexed | 2024-04-14T02:48:43Z |
| format | Article |
| id | doaj.art-36f29f52c9c94dad81b8a94008ce097c |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-14T02:48:43Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-36f29f52c9c94dad81b8a94008ce097c2022-12-22T02:16:24ZengDove Medical PressInfection and Drug Resistance1178-69732022-08-01Volume 154749475777553Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniaeLiang SCao HYing FZhang CShiwei Liang,1,2,* Huijun Cao,1,* Fei Ying,1 Chenchen Zhang2 1Centre for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Ying, Tel +86 13985509788, Email feiying@gmc.edu.cnAbstract: The report describes a 44-year-old female patient who died of the rare acute purulent pericarditis caused by Klebsiella pneumoniae (KP). The genomic analysis revealed an extensively drug-resistant ST11-K64 KP strain from five isolates (blood cultures, urine, ascites, pericardial effusion, and sputum). Several high virulence (hv) and carbapenem-resistant (CR) genes were identified in the pericardial effuse isolate. The isolates showed low resistance to healthy human serum. This study highlights the potential lethality of CR-hvKP infections in patients suffering from underlying comorbidities such as diabetes mellitus and chronic ailments.Keywords: purulent pericarditis, Klebsiella pneumoniae, carbapenem-resistance, hypervirulence, ST11, K64https://www.dovepress.com/report-of-a-fatal-purulent-pericarditis-case-caused-by-st11-k64-carbap-peer-reviewed-fulltext-article-IDRpurulent pericarditisklebsiella pneumoniaecarbapenem-resistancehypervirulencest11k64 |
| spellingShingle | Liang S Cao H Ying F Zhang C Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Infection and Drug Resistance purulent pericarditis klebsiella pneumoniae carbapenem-resistance hypervirulence st11 k64 |
| title | Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae |
| title_full | Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae |
| title_fullStr | Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae |
| title_full_unstemmed | Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae |
| title_short | Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae |
| title_sort | report of a fatal purulent pericarditis case caused by st11 k64 carbapenem resistant hypervirulent klebsiella pneumoniae |
| topic | purulent pericarditis klebsiella pneumoniae carbapenem-resistance hypervirulence st11 k64 |
| url | https://www.dovepress.com/report-of-a-fatal-purulent-pericarditis-case-caused-by-st11-k64-carbap-peer-reviewed-fulltext-article-IDR |
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