High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study
Background and aimsMany improvements have been made in the treatment of human immunodeficiency virus (HIV) in pediatric patients; however, challenges remain in terms of achieving normal growth, body composition, and metabolism during treatment, etc. Current nutritional recommendations are based on s...
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| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1220013/full |
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| author | Andrea Franco-Oliva Andrea Franco-Oliva Beatriz Adriana Pinzón-Navarro Beatriz Adriana Pinzón-Navarro Martha C. Martínez-Soto-Holguín Ximena León-Lara Javier Ordoñez-Ortega Ana Laura Pardo-Gutiérrez Martha Guevara-Cruz Martha Guevara-Cruz Azalia Avila-Nava Alda Daniela García-Guzmán Alda Daniela García-Guzmán Laura Guevara-Pedraza Isabel Medina-Vera Isabel Medina-Vera |
| author_facet | Andrea Franco-Oliva Andrea Franco-Oliva Beatriz Adriana Pinzón-Navarro Beatriz Adriana Pinzón-Navarro Martha C. Martínez-Soto-Holguín Ximena León-Lara Javier Ordoñez-Ortega Ana Laura Pardo-Gutiérrez Martha Guevara-Cruz Martha Guevara-Cruz Azalia Avila-Nava Alda Daniela García-Guzmán Alda Daniela García-Guzmán Laura Guevara-Pedraza Isabel Medina-Vera Isabel Medina-Vera |
| author_sort | Andrea Franco-Oliva |
| collection | DOAJ |
| description | Background and aimsMany improvements have been made in the treatment of human immunodeficiency virus (HIV) in pediatric patients; however, challenges remain in terms of achieving normal growth, body composition, and metabolism during treatment, etc. Current nutritional recommendations are based on studies performed in adults, with limited data on the HIV-infected pediatric population. Therefore, this study aimed to compare the resting energy expenditure (REE) of asymptomatic HIV-infected pediatric patients with healthy counterparts and to compare body composition, dietary intake, and physical activity between the two groups.MethodsThis was a cross-sectional study of asymptomatic HIV-infected children who were receiving antiretroviral therapy; the infected group was compared with the uninfected group, matched by age (± 6 months), sex, and body mass index (± 0.5 z-score). Participants were recruited between 2021 and 2022, as outpatients. In both groups, REE was determined by indirect calorimetry and body composition by bioelectrical impedance analysis and hand strength, measured using a hydraulic hand dynamometer.ResultsSeventy-eight participants were enrolled, where n = 39 HIV-infected children and n = 39 controls, with a mean age of 11.6 ± 3.4 years old. REE was significantly higher in the HIV group (1254.4 ± 334.7 kcal/day vs. 1124.7 ± 321 kcal/day, p = 0.013) than in the control group. Fat-free mass (FFM) was lower in the HIV group (28.2 ± 10.5 kg vs. 32 ± 11.2 kg, p = 0.001); this trend continued when the index skeletal muscle was evaluated (7.2 ± 1.2 vs. 7.6 ± 1.5, p = 0.04). The strength of the dominant hand was also lower in the HIV group (12 (8–18) kg vs. 20 (10.5–26) kg, p < 0.0001).ConclusionsChildren with asymptomatic HIV infection have higher REE than their uninfected peers. They also present decreased FFM, skeletal muscle mass index, and muscle strength. These parameters should be considered during nutritional assessment in this population to have a favorable impact on nutritional status and growth. |
| first_indexed | 2024-03-11T23:11:20Z |
| format | Article |
| id | doaj.art-36f3ac45bdb04f0b8f6d0af9de1f8890 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T23:11:20Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-36f3ac45bdb04f0b8f6d0af9de1f88902023-09-21T08:38:45ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-09-011010.3389/fnut.2023.12200131220013High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional studyAndrea Franco-Oliva0Andrea Franco-Oliva1Beatriz Adriana Pinzón-Navarro2Beatriz Adriana Pinzón-Navarro3Martha C. Martínez-Soto-Holguín4Ximena León-Lara5Javier Ordoñez-Ortega6Ana Laura Pardo-Gutiérrez7Martha Guevara-Cruz8Martha Guevara-Cruz9Azalia Avila-Nava10Alda Daniela García-Guzmán11Alda Daniela García-Guzmán12Laura Guevara-Pedraza13Isabel Medina-Vera14Isabel Medina-Vera15Departamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Ciudad de México, MexicoMaestría en Nutrición Clínica, Escuela de Dietética y Nutrición del ISSSTE, Ciudad de México, MéxicoServicio de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, Ciudad de México, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de México, MexicoServicio de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, Ciudad de México, MexicoInstitute of Immunology, Hannover Medical School, Hannover, GermanyDepartamento de Infectología Pediátrica, Instituto Nacional de Pediatría, Ciudad de México, MexicoDepartamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Ciudad de México, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de México, MexicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Nutrición y Ciencias Médicas Salvador Zubirán, Ciudad de México, MexicoUnidad de Investigación, Hospital Regional de Alta Especialidad de la Península de Yucatán, Mérida, Yucatán, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de México, MexicoServicio de Oncología Médica, Instituto Nacional de Pediatría, Ciudad de México, Mexico0Universidad Anahuac, Ciudad de México, MexicoDepartamento de Metodología de la Investigación, Instituto Nacional de Pediatría, Ciudad de México, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de México, MexicoBackground and aimsMany improvements have been made in the treatment of human immunodeficiency virus (HIV) in pediatric patients; however, challenges remain in terms of achieving normal growth, body composition, and metabolism during treatment, etc. Current nutritional recommendations are based on studies performed in adults, with limited data on the HIV-infected pediatric population. Therefore, this study aimed to compare the resting energy expenditure (REE) of asymptomatic HIV-infected pediatric patients with healthy counterparts and to compare body composition, dietary intake, and physical activity between the two groups.MethodsThis was a cross-sectional study of asymptomatic HIV-infected children who were receiving antiretroviral therapy; the infected group was compared with the uninfected group, matched by age (± 6 months), sex, and body mass index (± 0.5 z-score). Participants were recruited between 2021 and 2022, as outpatients. In both groups, REE was determined by indirect calorimetry and body composition by bioelectrical impedance analysis and hand strength, measured using a hydraulic hand dynamometer.ResultsSeventy-eight participants were enrolled, where n = 39 HIV-infected children and n = 39 controls, with a mean age of 11.6 ± 3.4 years old. REE was significantly higher in the HIV group (1254.4 ± 334.7 kcal/day vs. 1124.7 ± 321 kcal/day, p = 0.013) than in the control group. Fat-free mass (FFM) was lower in the HIV group (28.2 ± 10.5 kg vs. 32 ± 11.2 kg, p = 0.001); this trend continued when the index skeletal muscle was evaluated (7.2 ± 1.2 vs. 7.6 ± 1.5, p = 0.04). The strength of the dominant hand was also lower in the HIV group (12 (8–18) kg vs. 20 (10.5–26) kg, p < 0.0001).ConclusionsChildren with asymptomatic HIV infection have higher REE than their uninfected peers. They also present decreased FFM, skeletal muscle mass index, and muscle strength. These parameters should be considered during nutritional assessment in this population to have a favorable impact on nutritional status and growth.https://www.frontiersin.org/articles/10.3389/fnut.2023.1220013/fullHIV-infectedchildrenadolescentsresting energy expenditurefat free masshandgrip strength |
| spellingShingle | Andrea Franco-Oliva Andrea Franco-Oliva Beatriz Adriana Pinzón-Navarro Beatriz Adriana Pinzón-Navarro Martha C. Martínez-Soto-Holguín Ximena León-Lara Javier Ordoñez-Ortega Ana Laura Pardo-Gutiérrez Martha Guevara-Cruz Martha Guevara-Cruz Azalia Avila-Nava Alda Daniela García-Guzmán Alda Daniela García-Guzmán Laura Guevara-Pedraza Isabel Medina-Vera Isabel Medina-Vera High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study Frontiers in Nutrition HIV-infected children adolescents resting energy expenditure fat free mass handgrip strength |
| title | High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study |
| title_full | High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study |
| title_fullStr | High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study |
| title_full_unstemmed | High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study |
| title_short | High resting energy expenditure, less fat-free mass, and less muscle strength in HIV-infected children: a matched, cross-sectional study |
| title_sort | high resting energy expenditure less fat free mass and less muscle strength in hiv infected children a matched cross sectional study |
| topic | HIV-infected children adolescents resting energy expenditure fat free mass handgrip strength |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1220013/full |
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