Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity

Monocarboxylate transporter 1 deficiency impacts CD8+ T lymphocytes proliferation and recruitment to adipose tissue during obesity

Summary: Lactate sits at the crossroad of metabolism, immunity, and inflammation. The expression of cellular lactate transporter MCT1 (known as Slc16a1) increases during immune cell activation to cope with the metabolic reprogramming. We investigated the impact of MCT1 deficiency on CD8+ T cell func...

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Bibliographic Details
Main Authors: C. Macchi, A. Moregola, M.F. Greco, M. Svecla, F. Bonacina, S. Dhup, R.K. Dadhich, M. Audano, P. Sonveaux, C. Mauro, N. Mitro, M. Ruscica, G.D. Norata
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:iScience
Subjects:
Biological sciences
Immunology
Metabolomics
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222007064

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