Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage

Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage

Sirtuin 3 (SIRT3) is the primary mitochondrial deacetylase that controls the antioxidant pathway and energy metabolism. We previously found that renal <i>Sirt3</i> expression and activity were reduced in mice with type 2 diabetic nephropathy associated with oxidative stress and mitochond...

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Bibliographic Details
Main Authors: Monica Locatelli, Daniela Macconi, Daniela Corna, Domenico Cerullo, Daniela Rottoli, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
high-fat-diet
sirtuin 3
oxidative stress
mitochondrial damage
lipotoxicity
kidney damage
Online Access:https://www.mdpi.com/1422-0067/23/15/8345

Internet

https://www.mdpi.com/1422-0067/23/15/8345

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