CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review
In the human immunodeficiency virus (HIV)-infected population, especially HIV with concomitant tuberculosis (TB) or Hodgkin’s lymphoma (HL), numerous risk factors have been reported in recent years. Among them, the decreased CD4+ T cell count was recognized as the common risk factor. We report a cas...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-09-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0744 |
| _version_ | 1827808040226652160 |
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| author | Xiao Pingping Chen Xuyan Chen Yongquan Fan Wei Dong Zhigao Huang Jinmei Zhang Yi |
| author_facet | Xiao Pingping Chen Xuyan Chen Yongquan Fan Wei Dong Zhigao Huang Jinmei Zhang Yi |
| author_sort | Xiao Pingping |
| collection | DOAJ |
| description | In the human immunodeficiency virus (HIV)-infected population, especially HIV with concomitant tuberculosis (TB) or Hodgkin’s lymphoma (HL), numerous risk factors have been reported in recent years. Among them, the decreased CD4+ T cell count was recognized as the common risk factor. We report a case of a patient with HIV and TB and HL co-occurrence, in which patient’s CD4+ T cell count was inconsistent with disease. A 58-year-old male presented with fever and shortness of breath that persisted for 2 months. The patient had a 4-year history of HIV infection and underwent antiretroviral therapy (ART) effectively. After blood test, computed tomography, bone biopsy, and lymphoma biopsy, the patient was diagnosed with skeletal TB and HL, underwent TB treatment and received ART, and underwent four cycles of chemotherapy. CD4+ T cell count was not decreased before diagnosed with TB/HL and increased in this case after the fourth cycle of chemotherapy. We collected and analyzed CD4+ T cell counts in our case and reviewed relevant literature. It is suggested that CD4+ T cell count may be insufficient to predict the risk of HIV-related disease, especially lymphoproliferative disorders. |
| first_indexed | 2024-03-11T22:05:41Z |
| format | Article |
| id | doaj.art-36f76706566f461fae7011f297a91bf3 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-03-11T22:05:41Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-36f76706566f461fae7011f297a91bf32023-09-25T06:05:32ZengDe GruyterOpen Life Sciences2391-54122023-09-01181S51710.1515/biol-2022-0744CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature reviewXiao Pingping0Chen Xuyan1Chen Yongquan2Fan Wei3Dong Zhigao4Huang Jinmei5Zhang Yi6Department of Hematology and Rheumatology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, P. R. ChinaDepartment of Hematology and Rheumatology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, P. R. ChinaDepartment of Hematology and Rheumatology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, P. R. ChinaDepartment of Hematology and Rheumatology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, P. R. ChinaDepartment of Hematology and Rheumatology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, P. R. ChinaDepartment of Hematology and Rheumatology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, P. R. ChinaDepartment of Hematology and Rheumatology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, P. R. ChinaIn the human immunodeficiency virus (HIV)-infected population, especially HIV with concomitant tuberculosis (TB) or Hodgkin’s lymphoma (HL), numerous risk factors have been reported in recent years. Among them, the decreased CD4+ T cell count was recognized as the common risk factor. We report a case of a patient with HIV and TB and HL co-occurrence, in which patient’s CD4+ T cell count was inconsistent with disease. A 58-year-old male presented with fever and shortness of breath that persisted for 2 months. The patient had a 4-year history of HIV infection and underwent antiretroviral therapy (ART) effectively. After blood test, computed tomography, bone biopsy, and lymphoma biopsy, the patient was diagnosed with skeletal TB and HL, underwent TB treatment and received ART, and underwent four cycles of chemotherapy. CD4+ T cell count was not decreased before diagnosed with TB/HL and increased in this case after the fourth cycle of chemotherapy. We collected and analyzed CD4+ T cell counts in our case and reviewed relevant literature. It is suggested that CD4+ T cell count may be insufficient to predict the risk of HIV-related disease, especially lymphoproliferative disorders.https://doi.org/10.1515/biol-2022-0744hivtuberculosishodgkin’s lymphomacd4+ t cellsantiretroviral therapy |
| spellingShingle | Xiao Pingping Chen Xuyan Chen Yongquan Fan Wei Dong Zhigao Huang Jinmei Zhang Yi CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review Open Life Sciences hiv tuberculosis hodgkin’s lymphoma cd4+ t cells antiretroviral therapy |
| title | CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review |
| title_full | CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review |
| title_fullStr | CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review |
| title_full_unstemmed | CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review |
| title_short | CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL: Case report and literature review |
| title_sort | cd4 t cell count in hiv tb co infection and co occurrence with hl case report and literature review |
| topic | hiv tuberculosis hodgkin’s lymphoma cd4+ t cells antiretroviral therapy |
| url | https://doi.org/10.1515/biol-2022-0744 |
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