Restoration of the molecular clock is tumor suppressive in neuroblastoma
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growth
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24196-4 |
| _version_ | 1818835376055255040 |
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| author | Myrthala Moreno-Smith Giorgio Milazzo Ling Tao Baharan Fekry Bokai Zhu Mahmoud A. Mohammad Simone Di Giacomo Roshan Borkar Karthik Reddy Kami Reddy Mario Capasso Sanjeev A. Vasudevan Pavel Sumazin John Hicks Nagireddy Putluri Giovanni Perini Kristin Eckel-Mahan Thomas P. Burris Eveline Barbieri |
| author_facet | Myrthala Moreno-Smith Giorgio Milazzo Ling Tao Baharan Fekry Bokai Zhu Mahmoud A. Mohammad Simone Di Giacomo Roshan Borkar Karthik Reddy Kami Reddy Mario Capasso Sanjeev A. Vasudevan Pavel Sumazin John Hicks Nagireddy Putluri Giovanni Perini Kristin Eckel-Mahan Thomas P. Burris Eveline Barbieri |
| author_sort | Myrthala Moreno-Smith |
| collection | DOAJ |
| description | MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growth |
| first_indexed | 2024-12-19T02:49:43Z |
| format | Article |
| id | doaj.art-36f78ce6f76041c49c8161f0733a70f4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:49:43Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-36f78ce6f76041c49c8161f0733a70f42022-12-21T20:38:42ZengNature PortfolioNature Communications2041-17232021-06-0112111610.1038/s41467-021-24196-4Restoration of the molecular clock is tumor suppressive in neuroblastomaMyrthala Moreno-Smith0Giorgio Milazzo1Ling Tao2Baharan Fekry3Bokai Zhu4Mahmoud A. Mohammad5Simone Di Giacomo6Roshan Borkar7Karthik Reddy Kami Reddy8Mario Capasso9Sanjeev A. Vasudevan10Pavel Sumazin11John Hicks12Nagireddy Putluri13Giovanni Perini14Kristin Eckel-Mahan15Thomas P. Burris16Eveline Barbieri17Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pharmacy and Biotechnology, University of BolognaDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineInstitute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Department of Medicine, Division of Endocrinology and Metabolism, Aging Institute of UPMC, University of Pittsburgh School of MedicineDepartment of Pediatrics, Children’s Nutrition Research Center, US Department of Agriculture, Agricultural Research Service, Baylor College of MedicineDepartment of Pharmacy and Biotechnology, University of BolognaDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di NapoliDivision of Pediatric Surgery, Michael E. DeBakey Department of Surgery, Baylor College of MedicineDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pathology and Immunology, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Pharmacy and Biotechnology, University of BolognaInstitute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of PharmacyDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineMYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growthhttps://doi.org/10.1038/s41467-021-24196-4 |
| spellingShingle | Myrthala Moreno-Smith Giorgio Milazzo Ling Tao Baharan Fekry Bokai Zhu Mahmoud A. Mohammad Simone Di Giacomo Roshan Borkar Karthik Reddy Kami Reddy Mario Capasso Sanjeev A. Vasudevan Pavel Sumazin John Hicks Nagireddy Putluri Giovanni Perini Kristin Eckel-Mahan Thomas P. Burris Eveline Barbieri Restoration of the molecular clock is tumor suppressive in neuroblastoma Nature Communications |
| title | Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_full | Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_fullStr | Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_full_unstemmed | Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_short | Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_sort | restoration of the molecular clock is tumor suppressive in neuroblastoma |
| url | https://doi.org/10.1038/s41467-021-24196-4 |
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