Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells

Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells

By virtue of mitochondrial control of energy production, reactive oxygen species (ROS) generation, and maintenance of Ca<sup>2+</sup> homeostasis, mitochondria play an essential role in modulating T cell function. The mitochondrial Ca<sup>2+</sup> uniporter (MCU) is the pore-...

Full description

Bibliographic Details
Main Authors: Priska Jost, Franziska Klein, Benjamin Brand, Vanessa Wahl, Amanda Wyatt, Daniela Yildiz, Ulrich Boehm, Barbara A. Niemeyer, Martin Vaeth, Dalia Alansary
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial calcium uniporter
regulatory T cells
suppressive capacity
Online Access:https://www.mdpi.com/1422-0067/24/9/7772

Internet

https://www.mdpi.com/1422-0067/24/9/7772

Similar Items