Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer
<p>Abstract</p> <p>The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of bot...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2003-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://www.molecular-cancer.com/content/2/1/10 |
| _version_ | 1818325958615105536 |
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| author | Adrian Thomas E Hennig Rene Ding Xian-Zhong |
| author_facet | Adrian Thomas E Hennig Rene Ding Xian-Zhong |
| author_sort | Adrian Thomas E |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.</p> |
| first_indexed | 2024-12-13T11:52:45Z |
| format | Article |
| id | doaj.art-36f923c0cb384cb796ad9b76327e8297 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-13T11:52:45Z |
| publishDate | 2003-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-36f923c0cb384cb796ad9b76327e82972022-12-21T23:47:18ZengBMCMolecular Cancer1476-45982003-01-01211010.1186/1476-4598-2-10Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancerAdrian Thomas EHennig ReneDing Xian-Zhong<p>Abstract</p> <p>The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.</p>http://www.molecular-cancer.com/content/2/1/10pancreatic cancercyclooxygenaselipoxygenase |
| spellingShingle | Adrian Thomas E Hennig Rene Ding Xian-Zhong Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer Molecular Cancer pancreatic cancer cyclooxygenase lipoxygenase |
| title | Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer |
| title_full | Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer |
| title_fullStr | Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer |
| title_full_unstemmed | Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer |
| title_short | Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer |
| title_sort | lipoxygenase and cyclooxygenase metabolism new insights in treatment and chemoprevention of pancreatic cancer |
| topic | pancreatic cancer cyclooxygenase lipoxygenase |
| url | http://www.molecular-cancer.com/content/2/1/10 |
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