Precision medicine for adjuvant chemotherapy of resected colorectal cancer
Abstract Colorectal cancer (CRC) is the most common cancer and the second leading cause of cancer death in Japan. Surgical resection is the only curative option for localized disease. However, undetectable micrometastases remaining after curative surgery may cause disease recurrence. Adjuvant chemot...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-11-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12397 |
| _version_ | 1830131529805725696 |
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| author | Yuji Miyamoto Yukiharu Hiyoshi Hiroshi Sawayama Ryuma Tokunaga Hideo Baba |
| author_facet | Yuji Miyamoto Yukiharu Hiyoshi Hiroshi Sawayama Ryuma Tokunaga Hideo Baba |
| author_sort | Yuji Miyamoto |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is the most common cancer and the second leading cause of cancer death in Japan. Surgical resection is the only curative option for localized disease. However, undetectable micrometastases remaining after curative surgery may cause disease recurrence. Adjuvant chemotherapy aims to eradicate these micrometastases to improve the cure rate. Unfortunately, few reliable prognostic and predictive markers are available that identify patients at high risk for CRC during early‐stage disease. However, promising biomarkers may become available in the near future. Such biomarkers provide information for stratifying a patient's risk and for selecting the optimal treatment. Here, we provide an overview of current relevant prognostic and predictive biomarkers applicable to adjuvant treatment of early‐stage CRC and focus on the future of this field. |
| first_indexed | 2024-12-17T06:17:21Z |
| format | Article |
| id | doaj.art-36f92b5210de45148aa69febe05352c7 |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-12-17T06:17:21Z |
| publishDate | 2020-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-36f92b5210de45148aa69febe05352c72022-12-21T22:00:28ZengWileyAnnals of Gastroenterological Surgery2475-03282020-11-014663564510.1002/ags3.12397Precision medicine for adjuvant chemotherapy of resected colorectal cancerYuji Miyamoto0Yukiharu Hiyoshi1Hiroshi Sawayama2Ryuma Tokunaga3Hideo Baba4Department of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Kumamoto JapanAbstract Colorectal cancer (CRC) is the most common cancer and the second leading cause of cancer death in Japan. Surgical resection is the only curative option for localized disease. However, undetectable micrometastases remaining after curative surgery may cause disease recurrence. Adjuvant chemotherapy aims to eradicate these micrometastases to improve the cure rate. Unfortunately, few reliable prognostic and predictive markers are available that identify patients at high risk for CRC during early‐stage disease. However, promising biomarkers may become available in the near future. Such biomarkers provide information for stratifying a patient's risk and for selecting the optimal treatment. Here, we provide an overview of current relevant prognostic and predictive biomarkers applicable to adjuvant treatment of early‐stage CRC and focus on the future of this field.https://doi.org/10.1002/ags3.12397adjuvant chemotherapycolorectal cancerprecision medicinepredictive markerprognostic marker |
| spellingShingle | Yuji Miyamoto Yukiharu Hiyoshi Hiroshi Sawayama Ryuma Tokunaga Hideo Baba Precision medicine for adjuvant chemotherapy of resected colorectal cancer Annals of Gastroenterological Surgery adjuvant chemotherapy colorectal cancer precision medicine predictive marker prognostic marker |
| title | Precision medicine for adjuvant chemotherapy of resected colorectal cancer |
| title_full | Precision medicine for adjuvant chemotherapy of resected colorectal cancer |
| title_fullStr | Precision medicine for adjuvant chemotherapy of resected colorectal cancer |
| title_full_unstemmed | Precision medicine for adjuvant chemotherapy of resected colorectal cancer |
| title_short | Precision medicine for adjuvant chemotherapy of resected colorectal cancer |
| title_sort | precision medicine for adjuvant chemotherapy of resected colorectal cancer |
| topic | adjuvant chemotherapy colorectal cancer precision medicine predictive marker prognostic marker |
| url | https://doi.org/10.1002/ags3.12397 |
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