Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume
<p>Abstract</p> <p>Background</p> <p>Pericardial adipose tissue (PAT) has been shown to be an independent predictor of coronary artery disease. To date its assessment has been restricted to the use of surrogate echocardiographic indices such as measurement of epicardial...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-05-01
|
| Series: | Journal of Cardiovascular Magnetic Resonance |
| Online Access: | http://www.jcmr-online.com/content/11/1/15 |
| _version_ | 1797204448132464640 |
|---|---|
| author | Sanders Prashanthan Lau Dennis H Piantadosi Cynthia Duncan Rae F Dundon Benjamin K Carbone Angelo Psaltis Peter J Worthley Matthew I Nelson Adam J Wittert Gary A Worthley Stephen G |
| author_facet | Sanders Prashanthan Lau Dennis H Piantadosi Cynthia Duncan Rae F Dundon Benjamin K Carbone Angelo Psaltis Peter J Worthley Matthew I Nelson Adam J Wittert Gary A Worthley Stephen G |
| author_sort | Sanders Prashanthan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Pericardial adipose tissue (PAT) has been shown to be an independent predictor of coronary artery disease. To date its assessment has been restricted to the use of surrogate echocardiographic indices such as measurement of epicardial fat thickness over the right ventricular free wall, which have limitations. Cardiovascular magnetic resonance (CMR) offers the potential to non-invasively assess total PAT, however like other imaging modalities, CMR has not yet been validated for this purpose. Thus, we sought to describe a novel technique for assessing total PAT with validation in an ovine model.</p> <p>Methods</p> <p>11 merino sheep were studied. A standard clinical series of ventricular short axis CMR images (1.5T Siemens Sonata) were obtained during mechanical ventilation breath-holds. Beginning at the mitral annulus, consecutive end-diastolic ventricular images were used to determine the area and volume of epicardial, paracardial and pericardial adipose tissue. In addition adipose thickness was measured at the right ventricular free wall. Following euthanasia, the paracardial adipose tissue was removed from the ventricle and weighed to allow comparison with corresponding CMR measurements.</p> <p>Results</p> <p>There was a strong correlation between CMR-derived paracardial adipose tissue volume and <it>ex vivo </it>paracardial mass (R<sup>2 </sup>= 0.89, p < 0.001). In contrast, CMR measurements of corresponding RV free wall paracardial adipose thickness did not correlate with <it>ex vivo </it>paracardial mass (R<sup>2 </sup>= 0.003, p = 0.878).</p> <p>Conclusion</p> <p>In this ovine model, CMR-derived paracardial adipose tissue volume, but not the corresponding and conventional measure of paracardial adipose thickness over the RV free wall, accurately reflected paracardial adipose tissue mass. This study validates for the first time, the use of clinically utilised CMR sequences for the accurate and reproducible assessment of pericardial adiposity. Furthermore this non-invasive modality does not use ionising radiation and therefore is ideally suited for future studies of PAT and its role in cardiovascular risk prediction and disease in clinical practice.</p> |
| first_indexed | 2024-04-13T01:27:21Z |
| format | Article |
| id | doaj.art-36fcf58ff7394bf593ce9cd901002c4b |
| institution | Directory Open Access Journal |
| issn | 1097-6647 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:35:23Z |
| publishDate | 2009-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-36fcf58ff7394bf593ce9cd901002c4b2024-04-16T17:00:03ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2009-05-011111510.1186/1532-429X-11-15Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volumeSanders PrashanthanLau Dennis HPiantadosi CynthiaDuncan Rae FDundon Benjamin KCarbone AngeloPsaltis Peter JWorthley Matthew INelson Adam JWittert Gary AWorthley Stephen G<p>Abstract</p> <p>Background</p> <p>Pericardial adipose tissue (PAT) has been shown to be an independent predictor of coronary artery disease. To date its assessment has been restricted to the use of surrogate echocardiographic indices such as measurement of epicardial fat thickness over the right ventricular free wall, which have limitations. Cardiovascular magnetic resonance (CMR) offers the potential to non-invasively assess total PAT, however like other imaging modalities, CMR has not yet been validated for this purpose. Thus, we sought to describe a novel technique for assessing total PAT with validation in an ovine model.</p> <p>Methods</p> <p>11 merino sheep were studied. A standard clinical series of ventricular short axis CMR images (1.5T Siemens Sonata) were obtained during mechanical ventilation breath-holds. Beginning at the mitral annulus, consecutive end-diastolic ventricular images were used to determine the area and volume of epicardial, paracardial and pericardial adipose tissue. In addition adipose thickness was measured at the right ventricular free wall. Following euthanasia, the paracardial adipose tissue was removed from the ventricle and weighed to allow comparison with corresponding CMR measurements.</p> <p>Results</p> <p>There was a strong correlation between CMR-derived paracardial adipose tissue volume and <it>ex vivo </it>paracardial mass (R<sup>2 </sup>= 0.89, p < 0.001). In contrast, CMR measurements of corresponding RV free wall paracardial adipose thickness did not correlate with <it>ex vivo </it>paracardial mass (R<sup>2 </sup>= 0.003, p = 0.878).</p> <p>Conclusion</p> <p>In this ovine model, CMR-derived paracardial adipose tissue volume, but not the corresponding and conventional measure of paracardial adipose thickness over the RV free wall, accurately reflected paracardial adipose tissue mass. This study validates for the first time, the use of clinically utilised CMR sequences for the accurate and reproducible assessment of pericardial adiposity. Furthermore this non-invasive modality does not use ionising radiation and therefore is ideally suited for future studies of PAT and its role in cardiovascular risk prediction and disease in clinical practice.</p>http://www.jcmr-online.com/content/11/1/15 |
| spellingShingle | Sanders Prashanthan Lau Dennis H Piantadosi Cynthia Duncan Rae F Dundon Benjamin K Carbone Angelo Psaltis Peter J Worthley Matthew I Nelson Adam J Wittert Gary A Worthley Stephen G Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume Journal of Cardiovascular Magnetic Resonance |
| title | Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume |
| title_full | Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume |
| title_fullStr | Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume |
| title_full_unstemmed | Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume |
| title_short | Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume |
| title_sort | validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume |
| url | http://www.jcmr-online.com/content/11/1/15 |
| work_keys_str_mv | AT sandersprashanthan validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT laudennish validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT piantadosicynthia validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT duncanraef validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT dundonbenjamink validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT carboneangelo validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT psaltispeterj validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT worthleymatthewi validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT nelsonadamj validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT wittertgarya validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume AT worthleystepheng validationofcardiovascularmagneticresonanceassessmentofpericardialadiposetissuevolume |