A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes
Abstract Background Oral squamous cell carcinoma (OSCC) is the most frequent tumor of the head and neck. The glycolysis-related genes and immune-related genes have been proven prognostic values in various cancers. Our study aimed to test the prognostic value of glycolysis-immune-related genes in OSC...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-022-02358-0 |
| _version_ | 1811315089922326528 |
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| author | Yi Liu Tong Wang Ronghua Li |
| author_facet | Yi Liu Tong Wang Ronghua Li |
| author_sort | Yi Liu |
| collection | DOAJ |
| description | Abstract Background Oral squamous cell carcinoma (OSCC) is the most frequent tumor of the head and neck. The glycolysis-related genes and immune-related genes have been proven prognostic values in various cancers. Our study aimed to test the prognostic value of glycolysis-immune-related genes in OSCC. Methods Data of OSCC patients were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Enrichment analysis was applied to the glycolysis- and immune-related genes screened by differential expression analysis. Univariate Cox and LASSO Cox analyses were used to filtrate the genes related to the prognosis of OSCC and to construct Risk Score model. Results A Risk Score model was constructed by six glycolysis-immune-related genes (including ALDOC, VEGFA, HRG, PADI3, IGSF11 and MIPOL1). High risk OSCC patients (Risk Score >−0.3075) had significantly worse overall survival than that of low risk patients (Risk Score <−0.3075). Conclusions The Risk Score model constructed basing on 6 glycolysis-immune-related genes was reliable in stratifying OSCC patients with different prognosis. |
| first_indexed | 2024-04-13T11:24:04Z |
| format | Article |
| id | doaj.art-37001a18c37d4ed39427e4e0f334e484 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-13T11:24:04Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-37001a18c37d4ed39427e4e0f334e4842022-12-22T02:48:44ZengBMCBMC Oral Health1472-68312022-08-0122111110.1186/s12903-022-02358-0A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genesYi Liu0Tong Wang1Ronghua Li2Department of Stomatology, Tianjin First Central Hospital, Nankai DistrictDepartment of Stomatology, Tianjin First Central Hospital, Nankai DistrictDepartment of Stomatology, Tianjin First Central Hospital, Nankai DistrictAbstract Background Oral squamous cell carcinoma (OSCC) is the most frequent tumor of the head and neck. The glycolysis-related genes and immune-related genes have been proven prognostic values in various cancers. Our study aimed to test the prognostic value of glycolysis-immune-related genes in OSCC. Methods Data of OSCC patients were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Enrichment analysis was applied to the glycolysis- and immune-related genes screened by differential expression analysis. Univariate Cox and LASSO Cox analyses were used to filtrate the genes related to the prognosis of OSCC and to construct Risk Score model. Results A Risk Score model was constructed by six glycolysis-immune-related genes (including ALDOC, VEGFA, HRG, PADI3, IGSF11 and MIPOL1). High risk OSCC patients (Risk Score >−0.3075) had significantly worse overall survival than that of low risk patients (Risk Score <−0.3075). Conclusions The Risk Score model constructed basing on 6 glycolysis-immune-related genes was reliable in stratifying OSCC patients with different prognosis.https://doi.org/10.1186/s12903-022-02358-0Oral squamous cell carcinoma (OSCC)GlycolysisRisk ScorePrognosisNOMOGRAM |
| spellingShingle | Yi Liu Tong Wang Ronghua Li A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes BMC Oral Health Oral squamous cell carcinoma (OSCC) Glycolysis Risk Score Prognosis NOMOGRAM |
| title | A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes |
| title_full | A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes |
| title_fullStr | A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes |
| title_full_unstemmed | A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes |
| title_short | A prognostic Risk Score model for oral squamous cell carcinoma constructed by 6 glycolysis-immune-related genes |
| title_sort | prognostic risk score model for oral squamous cell carcinoma constructed by 6 glycolysis immune related genes |
| topic | Oral squamous cell carcinoma (OSCC) Glycolysis Risk Score Prognosis NOMOGRAM |
| url | https://doi.org/10.1186/s12903-022-02358-0 |
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