Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell–Mediated Antitumor Activity

Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell–Mediated Antitumor Activity

N6-methyladenosine (m6A) has been reported as an important mechanism of post-transcriptional regulation. Programmed death ligand 1 (PD-L1) is a primary immune inhibitory molecule expressed on tumor cells that promotes immune evasion. In addition, seven in absentia homolog 2 (Siah2), a RING E3 ubiqui...

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Bibliographic Details
Main Authors: Hao Zheng, Wen-juan Zheng, Zhen-guang Wang, Yuan-ping Tao, Zhi-ping Huang, Le Yang, Liu Ouyang, Zhi-qing Duan, Yi-nuo Zhang, Bo-ning Chen, Dai-min Xiang, Gang Jin, Lu Fang, Fan Zhou, Bo Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
N6-methyladenosine
METTL14
Siah2
PD-L1
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.845193/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.845193/full

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