Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathy
AIM: To explore the efficacy of preoperative intravitreal injection of conbercept combined with 25G+ pars plana vitrectomy(PPV)in the treatment of proliferative diabetic retinopathy(PDR).METHODS: The clinical data of 154 patients(176 eyes)with PDR admitted to our hospital from January 2019 to June 2...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-10-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2023/10/202310024.pdf |
| _version_ | 1797681983064637440 |
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| author | Yan-Hui Han Nan Zhao Fan-Chao Meng Guang-Wei Yu Dong-Lin Wang |
| author_facet | Yan-Hui Han Nan Zhao Fan-Chao Meng Guang-Wei Yu Dong-Lin Wang |
| author_sort | Yan-Hui Han |
| collection | DOAJ |
| description | AIM: To explore the efficacy of preoperative intravitreal injection of conbercept combined with 25G+ pars plana vitrectomy(PPV)in the treatment of proliferative diabetic retinopathy(PDR).METHODS: The clinical data of 154 patients(176 eyes)with PDR admitted to our hospital from January 2019 to June 2021 were collected for retrospective analysis. According to the treatment methods, 80 patients(92 eyes)in combined treatment group were treated with preoperative intravitreal injection of conbercept combined with 25G+PPV, and 74 patients(84 eyes)in control group were given 25G+PPV only. The postoperative clinical efficacy and levels of adipokines [adiponectin(APN), retinol binding protein 4(RBP4)] before and after surgery were compared between both groups of patients.RESULTS: The combined treatment group showed better clinical efficacy than the control group at 1mo after surgery(P<0.05). Both groups had lower RBP4 levels at 3mo after surgery(P<0.05), with the combined treatment group showing a lower level than the control group(P<0.05). Serum APN levels significantly increased in both groups after surgery(P<0.05), with the combined treatment group having a higher level than the control group(P<0.05). The combined treatment group had lower incidence rates of retinal proliferation and postoperative complications after than the control group 3mo of follow-up(P<0.05).CONCLUSION: Preoperative intravitreal injection of conbercept combined with 25G+PPV is beneficial in improving the therapeutic effect of PDR and reducing the incidence rates of complications, which may be related to the regulations of the expressions of adipokines. |
| first_indexed | 2024-03-11T23:52:56Z |
| format | Article |
| id | doaj.art-3701d825601e464fb009c9161a0a9b1d |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-11T23:52:56Z |
| publishDate | 2023-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-3701d825601e464fb009c9161a0a9b1d2023-09-19T03:02:27ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-10-0123101732173610.3980/j.issn.1672-5123.2023.10.24202310024Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathyYan-Hui Han0Nan Zhao1Fan-Chao Meng2Guang-Wei Yu3Dong-Lin Wang4Department of Fundus, Jinan Mingshui Eye Hospital, Jinan 250200, Shandong Province, ChinaDepartment of Fundus, Jinan Mingshui Eye Hospital, Jinan 250200, Shandong Province, ChinaDepartment of Fundus, Jinan Mingshui Eye Hospital, Jinan 250200, Shandong Province, ChinaDepartment of Fundus, Jinan Mingshui Eye Hospital, Jinan 250200, Shandong Province, ChinaDepartment of Fundus, Jinan Mingshui Eye Hospital, Jinan 250200, Shandong Province, ChinaAIM: To explore the efficacy of preoperative intravitreal injection of conbercept combined with 25G+ pars plana vitrectomy(PPV)in the treatment of proliferative diabetic retinopathy(PDR).METHODS: The clinical data of 154 patients(176 eyes)with PDR admitted to our hospital from January 2019 to June 2021 were collected for retrospective analysis. According to the treatment methods, 80 patients(92 eyes)in combined treatment group were treated with preoperative intravitreal injection of conbercept combined with 25G+PPV, and 74 patients(84 eyes)in control group were given 25G+PPV only. The postoperative clinical efficacy and levels of adipokines [adiponectin(APN), retinol binding protein 4(RBP4)] before and after surgery were compared between both groups of patients.RESULTS: The combined treatment group showed better clinical efficacy than the control group at 1mo after surgery(P<0.05). Both groups had lower RBP4 levels at 3mo after surgery(P<0.05), with the combined treatment group showing a lower level than the control group(P<0.05). Serum APN levels significantly increased in both groups after surgery(P<0.05), with the combined treatment group having a higher level than the control group(P<0.05). The combined treatment group had lower incidence rates of retinal proliferation and postoperative complications after than the control group 3mo of follow-up(P<0.05).CONCLUSION: Preoperative intravitreal injection of conbercept combined with 25G+PPV is beneficial in improving the therapeutic effect of PDR and reducing the incidence rates of complications, which may be related to the regulations of the expressions of adipokines.http://ies.ijo.cn/cn_publish/2023/10/202310024.pdfproliferative diabetic retinopathy25g+ pars plana vitrectomyconberceptadiponectinretinol binding protein 4 |
| spellingShingle | Yan-Hui Han Nan Zhao Fan-Chao Meng Guang-Wei Yu Dong-Lin Wang Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathy Guoji Yanke Zazhi proliferative diabetic retinopathy 25g+ pars plana vitrectomy conbercept adiponectin retinol binding protein 4 |
| title | Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathy |
| title_full | Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathy |
| title_fullStr | Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathy |
| title_full_unstemmed | Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathy |
| title_short | Efficacy of preoperative intravitreal injection of Conbercept combined with 25G+ pars plana vitrectomy in the treatment of proliferative diabetic retinopathy |
| title_sort | efficacy of preoperative intravitreal injection of conbercept combined with 25g pars plana vitrectomy in the treatment of proliferative diabetic retinopathy |
| topic | proliferative diabetic retinopathy 25g+ pars plana vitrectomy conbercept adiponectin retinol binding protein 4 |
| url | http://ies.ijo.cn/cn_publish/2023/10/202310024.pdf |
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