A catalogue of human secreted proteins and its implications
Under both normal and pathological conditions, cells secrete variety of proteins through classical and non-classical secretory pathways into the extracellular space. Majority of these proteins represent pathophysiology of the cell from which it is secreted. Recently, though more than 92% of the prot...
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| Format: | Article |
| Language: | English |
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AIMS Press
2016-11-01
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| Series: | AIMS Biophysics |
| Subjects: | |
| Online Access: | http://www.aimspress.com/biophysics/article/1113/fulltext.html |
| _version_ | 1818014602110173184 |
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| author | Shivakumar Keerthikumar |
| author_facet | Shivakumar Keerthikumar |
| author_sort | Shivakumar Keerthikumar |
| collection | DOAJ |
| description | Under both normal and pathological conditions, cells secrete variety of proteins through classical and non-classical secretory pathways into the extracellular space. Majority of these proteins represent pathophysiology of the cell from which it is secreted. Recently, though more than 92% of the protein coding genes has been mapped by human proteome map project, but number of those proteins that constitutes secretome of the cell still remains elusive. Secreted proteins or the secretome can be accessible in bodily fluids and hence are considered as potential biomarkers to discriminate between healthy and diseased individuals. In order to facilitate the biomarker discovery and to further aid clinicians and scientists working in these arenas, we have compiled and catalogued secreted proteins from the human proteome using integrated bioinformatics approach. In this study, nearly 14% of the human proteome is likely to be secreted through classical and non-classical secretory pathways. Out of which, ~38% of these secreted proteins were found in extracellular vesicles including exosomes and shedding microvesicles. Among these secreted proteins, 94% were detected in human bodily fluids including blood, plasma, serum, saliva, semen, tear and urine. We anticipate that this high confidence list of secreted proteins could serve as a compendium of candidate biomarkers. In addition, the catalogue may provide functional insights in understanding the molecular mechanisms involved in various physiological and pathophysiological conditions of the cell. |
| first_indexed | 2024-04-14T06:47:26Z |
| format | Article |
| id | doaj.art-3702de39260e4d578da7ff0dde9c5724 |
| institution | Directory Open Access Journal |
| issn | 2377-9098 |
| language | English |
| last_indexed | 2024-04-14T06:47:26Z |
| publishDate | 2016-11-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Biophysics |
| spelling | doaj.art-3702de39260e4d578da7ff0dde9c57242022-12-22T02:07:08ZengAIMS PressAIMS Biophysics2377-90982016-11-013456357010.3934/biophy.2016.4.563biophys-03-00563A catalogue of human secreted proteins and its implicationsShivakumar Keerthikumar0Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, AustraliaUnder both normal and pathological conditions, cells secrete variety of proteins through classical and non-classical secretory pathways into the extracellular space. Majority of these proteins represent pathophysiology of the cell from which it is secreted. Recently, though more than 92% of the protein coding genes has been mapped by human proteome map project, but number of those proteins that constitutes secretome of the cell still remains elusive. Secreted proteins or the secretome can be accessible in bodily fluids and hence are considered as potential biomarkers to discriminate between healthy and diseased individuals. In order to facilitate the biomarker discovery and to further aid clinicians and scientists working in these arenas, we have compiled and catalogued secreted proteins from the human proteome using integrated bioinformatics approach. In this study, nearly 14% of the human proteome is likely to be secreted through classical and non-classical secretory pathways. Out of which, ~38% of these secreted proteins were found in extracellular vesicles including exosomes and shedding microvesicles. Among these secreted proteins, 94% were detected in human bodily fluids including blood, plasma, serum, saliva, semen, tear and urine. We anticipate that this high confidence list of secreted proteins could serve as a compendium of candidate biomarkers. In addition, the catalogue may provide functional insights in understanding the molecular mechanisms involved in various physiological and pathophysiological conditions of the cell.http://www.aimspress.com/biophysics/article/1113/fulltext.htmlsecretory; bioinformatics; integrative; proteomics; extracellular vesicles |
| spellingShingle | Shivakumar Keerthikumar A catalogue of human secreted proteins and its implications AIMS Biophysics secretory; bioinformatics; integrative; proteomics; extracellular vesicles |
| title | A catalogue of human secreted proteins and its implications |
| title_full | A catalogue of human secreted proteins and its implications |
| title_fullStr | A catalogue of human secreted proteins and its implications |
| title_full_unstemmed | A catalogue of human secreted proteins and its implications |
| title_short | A catalogue of human secreted proteins and its implications |
| title_sort | catalogue of human secreted proteins and its implications |
| topic | secretory; bioinformatics; integrative; proteomics; extracellular vesicles |
| url | http://www.aimspress.com/biophysics/article/1113/fulltext.html |
| work_keys_str_mv | AT shivakumarkeerthikumar acatalogueofhumansecretedproteinsanditsimplications AT shivakumarkeerthikumar catalogueofhumansecretedproteinsanditsimplications |