New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies
Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the morphological and functional regeneration of periphe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/24/13380 |
| _version_ | 1797503860322861056 |
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| author | Polina Klimovich Kseniya Rubina Veronika Sysoeva Ekaterina Semina |
| author_facet | Polina Klimovich Kseniya Rubina Veronika Sysoeva Ekaterina Semina |
| author_sort | Polina Klimovich |
| collection | DOAJ |
| description | Topical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the morphological and functional regeneration of peripheral nerves, calling for new treatment strategies that maximize nerve regeneration and recovery. This review presents the canonical view of the basic mechanisms of nerve regeneration and novel data on the role of exosomes and their transferred microRNAs in intracellular communication, regulation of axonal growth, Schwann cell migration and proliferation, and stromal cell functioning. An integrated comprehensive understanding of the current mechanistic underpinnings will open the venue for developing new clinical strategies to ensure full regeneration in the peripheral nervous system. |
| first_indexed | 2024-03-10T03:56:24Z |
| format | Article |
| id | doaj.art-3702f0fcdebc4f899d7e5846847e914a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:56:24Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3702f0fcdebc4f899d7e5846847e914a2023-11-23T08:45:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241338010.3390/ijms222413380New Frontiers in Peripheral Nerve Regeneration: Concerns and RemediesPolina Klimovich0Kseniya Rubina1Veronika Sysoeva2Ekaterina Semina3National Cardiology Research Center Ministry of Health of the Russian Federation, Institute of Experimental Cardiology, 121552 Moscow, RussiaFaculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, RussiaFaculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, RussiaNational Cardiology Research Center Ministry of Health of the Russian Federation, Institute of Experimental Cardiology, 121552 Moscow, RussiaTopical advances in studying molecular and cellular mechanisms responsible for regeneration in the peripheral nervous system have highlighted the ability of the nervous system to repair itself. Still, serious injuries represent a challenge for the morphological and functional regeneration of peripheral nerves, calling for new treatment strategies that maximize nerve regeneration and recovery. This review presents the canonical view of the basic mechanisms of nerve regeneration and novel data on the role of exosomes and their transferred microRNAs in intracellular communication, regulation of axonal growth, Schwann cell migration and proliferation, and stromal cell functioning. An integrated comprehensive understanding of the current mechanistic underpinnings will open the venue for developing new clinical strategies to ensure full regeneration in the peripheral nervous system.https://www.mdpi.com/1422-0067/22/24/13380peripheral nerve regenerationaxon growthSchwann cellsexosomesmicroRNAmultipotent stromal cells |
| spellingShingle | Polina Klimovich Kseniya Rubina Veronika Sysoeva Ekaterina Semina New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies International Journal of Molecular Sciences peripheral nerve regeneration axon growth Schwann cells exosomes microRNA multipotent stromal cells |
| title | New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies |
| title_full | New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies |
| title_fullStr | New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies |
| title_full_unstemmed | New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies |
| title_short | New Frontiers in Peripheral Nerve Regeneration: Concerns and Remedies |
| title_sort | new frontiers in peripheral nerve regeneration concerns and remedies |
| topic | peripheral nerve regeneration axon growth Schwann cells exosomes microRNA multipotent stromal cells |
| url | https://www.mdpi.com/1422-0067/22/24/13380 |
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