Adult Stem Cells for Bone Regeneration and Repair
The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major problem in our super-aging society. Bone regeneration is one of the main topics of concern in regenerative medicine. In recent years, stem cells have been employed in regenerative medicine with interesting...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2019.00268/full |
| _version_ | 1818454469052989440 |
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| author | Maria Rosa Iaquinta Elisa Mazzoni Ilaria Bononi John Charles Rotondo Chiara Mazziotta Monica Montesi Simone Sprio Anna Tampieri Mauro Tognon Fernanda Martini |
| author_facet | Maria Rosa Iaquinta Elisa Mazzoni Ilaria Bononi John Charles Rotondo Chiara Mazziotta Monica Montesi Simone Sprio Anna Tampieri Mauro Tognon Fernanda Martini |
| author_sort | Maria Rosa Iaquinta |
| collection | DOAJ |
| description | The regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major problem in our super-aging society. Bone regeneration is one of the main topics of concern in regenerative medicine. In recent years, stem cells have been employed in regenerative medicine with interesting results due to their self-renewal and differentiation capacity. Moreover, stem cells are able to secrete bioactive molecules and regulate the behavior of other cells in different host tissues. Bone regeneration process may improve effectively and rapidly when stem cells are used. To this purpose, stem cells are often employed with biomaterials/scaffolds and growth factors to accelerate bone healing at the fracture site. Briefly, this review will describe bone structure and the osteogenic differentiation of stem cells. In addition, the role of mesenchymal stem cells for bone repair/regrowth in the tissue engineering field and their recent progress in clinical applications will be discussed. |
| first_indexed | 2024-12-14T21:55:22Z |
| format | Article |
| id | doaj.art-37031edc371841dba606a9dd1855b276 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T21:55:22Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-37031edc371841dba606a9dd1855b2762022-12-21T22:46:07ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2019-11-01710.3389/fcell.2019.00268485383Adult Stem Cells for Bone Regeneration and RepairMaria Rosa Iaquinta0Elisa Mazzoni1Ilaria Bononi2John Charles Rotondo3Chiara Mazziotta4Monica Montesi5Simone Sprio6Anna Tampieri7Mauro Tognon8Fernanda Martini9Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, ItalyInstitute of Science and Technology for Ceramics, National Research Council, Faenza, ItalyInstitute of Science and Technology for Ceramics, National Research Council, Faenza, ItalyInstitute of Science and Technology for Ceramics, National Research Council, Faenza, ItalyDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, ItalyDepartment of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara, ItalyThe regeneration of bone fractures, resulting from trauma, osteoporosis or tumors, is a major problem in our super-aging society. Bone regeneration is one of the main topics of concern in regenerative medicine. In recent years, stem cells have been employed in regenerative medicine with interesting results due to their self-renewal and differentiation capacity. Moreover, stem cells are able to secrete bioactive molecules and regulate the behavior of other cells in different host tissues. Bone regeneration process may improve effectively and rapidly when stem cells are used. To this purpose, stem cells are often employed with biomaterials/scaffolds and growth factors to accelerate bone healing at the fracture site. Briefly, this review will describe bone structure and the osteogenic differentiation of stem cells. In addition, the role of mesenchymal stem cells for bone repair/regrowth in the tissue engineering field and their recent progress in clinical applications will be discussed.https://www.frontiersin.org/article/10.3389/fcell.2019.00268/fullstem cellregenerative medicinedifferentiationbonerepair |
| spellingShingle | Maria Rosa Iaquinta Elisa Mazzoni Ilaria Bononi John Charles Rotondo Chiara Mazziotta Monica Montesi Simone Sprio Anna Tampieri Mauro Tognon Fernanda Martini Adult Stem Cells for Bone Regeneration and Repair Frontiers in Cell and Developmental Biology stem cell regenerative medicine differentiation bone repair |
| title | Adult Stem Cells for Bone Regeneration and Repair |
| title_full | Adult Stem Cells for Bone Regeneration and Repair |
| title_fullStr | Adult Stem Cells for Bone Regeneration and Repair |
| title_full_unstemmed | Adult Stem Cells for Bone Regeneration and Repair |
| title_short | Adult Stem Cells for Bone Regeneration and Repair |
| title_sort | adult stem cells for bone regeneration and repair |
| topic | stem cell regenerative medicine differentiation bone repair |
| url | https://www.frontiersin.org/article/10.3389/fcell.2019.00268/full |
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