Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection.

Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection.

<h4>Background</h4>Regulation of immune responses is critical for controlling inflammation and disruption of this process can lead to tissue damage. We reported that CXCL13 was induced in fallopian tube tissue following C. trachomatis infection. Here, we examined the influence of the CXC...

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Main Authors: Janina Jiang, Ouafae Karimi, Sander Ouburg, Cheryl I Champion, Archana Khurana, Guangchao Liu, Amanda Freed, Jolein Pleijster, Nora Rozengurt, Jolande A Land, Helja-Marja Surcel, Aila' Tiitinen, Jorma Paavonen, Mitchell Kronenberg, Servaas A Morré, Kathleen A Kelly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23189125/?tool=EBI

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