Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients
BackgroundThe coronavirus disease-19 (COVID-19) is characterized with intense inflammatory response, cardiac involvement, and coagulopathy. Fibrinogen, as a biomarker for inflammation, cardiovascular disease, and coagulation, has not been fully investigated yet. The aim of this study was to assess t...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.734005/full |
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| author | Jingrui Sui Jingrui Sui Denis F. Noubouossie Sheetal Gandotra Liyun Cao |
| author_facet | Jingrui Sui Jingrui Sui Denis F. Noubouossie Sheetal Gandotra Liyun Cao |
| author_sort | Jingrui Sui |
| collection | DOAJ |
| description | BackgroundThe coronavirus disease-19 (COVID-19) is characterized with intense inflammatory response, cardiac involvement, and coagulopathy. Fibrinogen, as a biomarker for inflammation, cardiovascular disease, and coagulation, has not been fully investigated yet. The aim of this study was to assess the clinical application of fibrinogen in COVID-19 patients.MethodsWe retrospectively analyzed the demographic and laboratory characteristics of 119 COVID-19 patients in the University of Alabama of Birmingham Medical Center. Correlations of fibrinogen on admission with intensive care unit (ICU) admission, disease severity, and laboratory parameters were analyzed.ResultsAmong the 119 COVID-19 patients, 77.3% (92/119) had severe disease, and 59.5% (71/119) patients were admitted to the ICU. Elevated fibrinogen was detected in 67.2% (80/119) of the patients. Fibrinogen levels were significantly associated with inflammatory markers and disease severity, but not with cardiac injury biomarker high sensitivity troponin I. Patients with severe disease had increased fibrinogen levels upon admission compared to patients with non-severe disease (P = 0.001). Fibrinogen level at 528.0 mg/dl was the optimal cutoff to predict disease severity, with a sensitivity and specificity of 66.7% and 70.3% (area undty -60er the curve [AUC] 0.72, P = 0.0006).ConclusionsFibrinogen is commonly elevated in COVID-19 patients, especially in those with severe disease. Elevated fibrinogen correlates with excessive inflammation, disease severity, and ICU admission in COVID-19 patients. |
| first_indexed | 2024-12-21T06:05:35Z |
| format | Article |
| id | doaj.art-3703dac9f3e642a9963c88aee8d4ef0f |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-21T06:05:35Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-3703dac9f3e642a9963c88aee8d4ef0f2022-12-21T19:13:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-08-011110.3389/fcimb.2021.734005734005Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 PatientsJingrui Sui0Jingrui Sui1Denis F. Noubouossie2Sheetal Gandotra3Liyun Cao4Division of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Hematology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, ChinaDivision of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United StatesDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDivision of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, United StatesBackgroundThe coronavirus disease-19 (COVID-19) is characterized with intense inflammatory response, cardiac involvement, and coagulopathy. Fibrinogen, as a biomarker for inflammation, cardiovascular disease, and coagulation, has not been fully investigated yet. The aim of this study was to assess the clinical application of fibrinogen in COVID-19 patients.MethodsWe retrospectively analyzed the demographic and laboratory characteristics of 119 COVID-19 patients in the University of Alabama of Birmingham Medical Center. Correlations of fibrinogen on admission with intensive care unit (ICU) admission, disease severity, and laboratory parameters were analyzed.ResultsAmong the 119 COVID-19 patients, 77.3% (92/119) had severe disease, and 59.5% (71/119) patients were admitted to the ICU. Elevated fibrinogen was detected in 67.2% (80/119) of the patients. Fibrinogen levels were significantly associated with inflammatory markers and disease severity, but not with cardiac injury biomarker high sensitivity troponin I. Patients with severe disease had increased fibrinogen levels upon admission compared to patients with non-severe disease (P = 0.001). Fibrinogen level at 528.0 mg/dl was the optimal cutoff to predict disease severity, with a sensitivity and specificity of 66.7% and 70.3% (area undty -60er the curve [AUC] 0.72, P = 0.0006).ConclusionsFibrinogen is commonly elevated in COVID-19 patients, especially in those with severe disease. Elevated fibrinogen correlates with excessive inflammation, disease severity, and ICU admission in COVID-19 patients.https://www.frontiersin.org/articles/10.3389/fcimb.2021.734005/fullfibrinogencoronavirus disease 2019 (COVID-19)inflammationcardiovascular diseasecoagulation |
| spellingShingle | Jingrui Sui Jingrui Sui Denis F. Noubouossie Sheetal Gandotra Liyun Cao Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients Frontiers in Cellular and Infection Microbiology fibrinogen coronavirus disease 2019 (COVID-19) inflammation cardiovascular disease coagulation |
| title | Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients |
| title_full | Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients |
| title_fullStr | Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients |
| title_full_unstemmed | Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients |
| title_short | Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients |
| title_sort | elevated plasma fibrinogen is associated with excessive inflammation and disease severity in covid 19 patients |
| topic | fibrinogen coronavirus disease 2019 (COVID-19) inflammation cardiovascular disease coagulation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.734005/full |
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