Synthesis of 125I Labeled Estradiol-17-Hemisuccinate and Its Binding Study to Estrogen Receptors Using Scintillation Proximity Assay Method

Synthesis of 125I Labeled Estradiol-17-Hemisuccinate and Its Binding Study to Estrogen Receptors Using Scintillation Proximity Assay Method

Research was carried out to obtain a selective ligand which strongly bind to estrogen receptors through determination of binding affinity of estradiol-17β-hemisuccinate. Selectivity of these compounds for estrogen receptor was studied using Scintillation Proximity Assay (SPA) method. Primary reagen...

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Bibliographic Details
Main Authors: Y. Susilo, G. Mondrida, S. Setiyowati, Triningsih, W. Lestari, P. Widayati, C.N. Ardiyatno, A. Ariyanto, S. Darwati, L.B.S. Kardono, A. Yanuar
Format: Article
Language:English
Published: Center for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN) 2012-12-01
Series:Atom Indonesia
Subjects:
Indirect labeling
Estrogen receptor
Estradiol
Scintillation proximity assay
Binding affinity
MCF7
Online Access:http://aij.batan.go.id/index.php/aij/article/view/175

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