CD47 as a promising therapeutic target in oncology

CD47 as a promising therapeutic target in oncology

CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular phagocytosis by macrophages, determines life span of individual erythrocytes, regulates activation of immune cells, and manipu...

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Bibliographic Details
Main Authors: Hai Zhao, Shuangshuang Song, Junwei Ma, Zhiyong Yan, Hongwei Xie, Ying Feng, Shusheng Che
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
CD47
SIRPα
immune modulation
immunotherapies
cancer immunotherapy
atherosclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.757480/full

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