Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR
The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic silencing of the class II transactivator leads to d...
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Bibliographic Details
| Main Authors: |
Jake R. Thomas,
Anna Appios,
Emily F. Calderbank,
Nagisa Yoshida,
Xiaohui Zhao,
Russell S. Hamilton,
Ashley Moffett,
Andrew Sharkey,
Elisa Laurenti,
Courtney W. Hanna,
Naomi McGovern |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-37383-2
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