Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR
The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic silencing of the class II transactivator leads to d...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37383-2 |
| _version_ | 1797853706452992000 |
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| author | Jake R. Thomas Anna Appios Emily F. Calderbank Nagisa Yoshida Xiaohui Zhao Russell S. Hamilton Ashley Moffett Andrew Sharkey Elisa Laurenti Courtney W. Hanna Naomi McGovern |
| author_facet | Jake R. Thomas Anna Appios Emily F. Calderbank Nagisa Yoshida Xiaohui Zhao Russell S. Hamilton Ashley Moffett Andrew Sharkey Elisa Laurenti Courtney W. Hanna Naomi McGovern |
| author_sort | Jake R. Thomas |
| collection | DOAJ |
| description | The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic silencing of the class II transactivator leads to downregulation of HLA-DR in these cells. |
| first_indexed | 2024-04-09T19:53:59Z |
| format | Article |
| id | doaj.art-370741294d1d45e496cf44e8daffe8d6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T19:53:59Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-370741294d1d45e496cf44e8daffe8d62023-04-03T05:32:40ZengNature PortfolioNature Communications2041-17232023-03-0114111610.1038/s41467-023-37383-2Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DRJake R. Thomas0Anna Appios1Emily F. Calderbank2Nagisa Yoshida3Xiaohui Zhao4Russell S. Hamilton5Ashley Moffett6Andrew Sharkey7Elisa Laurenti8Courtney W. Hanna9Naomi McGovern10Centre for Trophoblast Research, University of CambridgeCentre for Trophoblast Research, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeCentre for Trophoblast Research, University of CambridgeCentre for Trophoblast Research, University of CambridgeCentre for Trophoblast Research, University of CambridgeCentre for Trophoblast Research, University of CambridgeCentre for Trophoblast Research, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeCentre for Trophoblast Research, University of CambridgeCentre for Trophoblast Research, University of CambridgeThe generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic silencing of the class II transactivator leads to downregulation of HLA-DR in these cells.https://doi.org/10.1038/s41467-023-37383-2 |
| spellingShingle | Jake R. Thomas Anna Appios Emily F. Calderbank Nagisa Yoshida Xiaohui Zhao Russell S. Hamilton Ashley Moffett Andrew Sharkey Elisa Laurenti Courtney W. Hanna Naomi McGovern Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR Nature Communications |
| title | Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR |
| title_full | Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR |
| title_fullStr | Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR |
| title_full_unstemmed | Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR |
| title_short | Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR |
| title_sort | primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced hla dr |
| url | https://doi.org/10.1038/s41467-023-37383-2 |
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