Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR

Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR

The generation of primitive macrophages remains a poorly understood process in humans. Here, the authors identify placental erythro-myeloid progenitors that give rise to foetal macrophages in the early human placenta and demonstrate that epigenetic silencing of the class II transactivator leads to d...

Full description

Bibliographic Details
Main Authors: Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W. Hanna, Naomi McGovern
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37383-2

Internet

https://doi.org/10.1038/s41467-023-37383-2

Similar Items