Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort Study
Maternal hematological disorders during pregnancy may pose a risk to the neurological development of newborns. To investigate the association between maternal hematological disorders during pregnancy and neurological outcomes in newborns, this mixed cohort study was conducted on 200 pregnant women d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/10/2014 |
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| author | Ebtisam Bakhsh Maan Alkhaldi Mostafa Shaban |
| author_facet | Ebtisam Bakhsh Maan Alkhaldi Mostafa Shaban |
| author_sort | Ebtisam Bakhsh |
| collection | DOAJ |
| description | Maternal hematological disorders during pregnancy may pose a risk to the neurological development of newborns. To investigate the association between maternal hematological disorders during pregnancy and neurological outcomes in newborns, this mixed cohort study was conducted on 200 pregnant women diagnosed with hematological disorders during pregnancy. Some cases have been identified in the past who have completed the pregnancy in full, as well as cases in pregnancy. Currently, the children of all mothers have been followed up to evaluate the neurological outcomes of the children at the age of three months. Logistic regression analysis was used to determine the association between maternal hematological disorders and neurological outcomes in newborns. Children born to mothers with hematological disorders had a higher risk of developmental delays (OR = 1.50, 95% CI = 0.90–2.50), cognitive impairments (OR = 1.80, 95% CI = 1.20–2.70), and motor impairments (OR = 1.60, 95% CI = 1.00–2.50) compared to children born to mothers without hematological disorders. Hemophilia was associated with the highest risk of neurological outcomes (developmental delay: OR = 2.80, 95% CI = 1.60–4.90; cognitive impairment: OR = 3.20, 95% CI = 2.00–5.10; motor impairment: OR = 2.60, 95% CI = 1.50–4.60). Conclusion: Our study suggests that maternal hematological disorders during pregnancy may increase the risk of negative neurological consequences in newborns. Further research is needed to identify potential mechanisms and explore preventive measures. |
| first_indexed | 2024-03-10T21:06:42Z |
| format | Article |
| id | doaj.art-3707abc7b21c47cdb8f835b2814beba6 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T21:06:42Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-3707abc7b21c47cdb8f835b2814beba62023-11-19T17:06:10ZengMDPI AGLife2075-17292023-10-011310201410.3390/life13102014Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort StudyEbtisam Bakhsh0Maan Alkhaldi1Mostafa Shaban2Clinical Sciences Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi ArabiaCollege of Medicine, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh 13317, Saudi ArabiaCollege of Nursing, Jouf University, Sakaka 72388, Saudi ArabiaMaternal hematological disorders during pregnancy may pose a risk to the neurological development of newborns. To investigate the association between maternal hematological disorders during pregnancy and neurological outcomes in newborns, this mixed cohort study was conducted on 200 pregnant women diagnosed with hematological disorders during pregnancy. Some cases have been identified in the past who have completed the pregnancy in full, as well as cases in pregnancy. Currently, the children of all mothers have been followed up to evaluate the neurological outcomes of the children at the age of three months. Logistic regression analysis was used to determine the association between maternal hematological disorders and neurological outcomes in newborns. Children born to mothers with hematological disorders had a higher risk of developmental delays (OR = 1.50, 95% CI = 0.90–2.50), cognitive impairments (OR = 1.80, 95% CI = 1.20–2.70), and motor impairments (OR = 1.60, 95% CI = 1.00–2.50) compared to children born to mothers without hematological disorders. Hemophilia was associated with the highest risk of neurological outcomes (developmental delay: OR = 2.80, 95% CI = 1.60–4.90; cognitive impairment: OR = 3.20, 95% CI = 2.00–5.10; motor impairment: OR = 2.60, 95% CI = 1.50–4.60). Conclusion: Our study suggests that maternal hematological disorders during pregnancy may increase the risk of negative neurological consequences in newborns. Further research is needed to identify potential mechanisms and explore preventive measures.https://www.mdpi.com/2075-1729/13/10/2014hematological disorderspregnancyneurological outcomesdevelopmental delaycognitive impairmentmotor impairment |
| spellingShingle | Ebtisam Bakhsh Maan Alkhaldi Mostafa Shaban Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort Study Life hematological disorders pregnancy neurological outcomes developmental delay cognitive impairment motor impairment |
| title | Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort Study |
| title_full | Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort Study |
| title_fullStr | Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort Study |
| title_full_unstemmed | Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort Study |
| title_short | Exploring the Link between Maternal Hematological Disorders during Pregnancy and Neurological Development in Newborns: Mixed Cohort Study |
| title_sort | exploring the link between maternal hematological disorders during pregnancy and neurological development in newborns mixed cohort study |
| topic | hematological disorders pregnancy neurological outcomes developmental delay cognitive impairment motor impairment |
| url | https://www.mdpi.com/2075-1729/13/10/2014 |
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